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Biosemiotics is dedicated to building a bridge between biology, philosophy, linguistics, and the communication sciences. Biosemiotic research is concerned with the study of signs and meaning in living organisms and systems. Its main challenge is to naturalize biological meaning and information by building on the belief that signs are fundamental, constitutive components of the living world. Biosemiotics has triggered rethinking of fundamental assumptions in both biology and semiotics. In this view, biology should recognize the semiotic nature of life and reshape its theories and methodology accordingly while semiotics and the humanities should acknowledge the existence of signs beyond the human realm. Biosemiotics is at the cutting edge of research on the fundamentals of life. By challenging traditional assumptions on the nature of life and suggesting alternative perspectives, it opens up exciting new research paths.