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Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry. Fundamental articles may address the general principles of chemical measurement science without directly studying existing analytical methodology as long as what is discussed relates to an important chemical parameter. Articles may be theoretical or they may report experimental results. They may contribute to any phase of analytical operations including sampling, measurements, and data analysis; the articles should target fields including, but not limited to, bioanalytical chemistry, bioengineering, chemical analysis, environmental sciences, forensics and medical sciences. Topics commonly include chemical reactions and selectivity, chemometrics and data processing, electrochemistry, elemental and molecular characterization, imaging, instrumentation, mass spectrometry, microscale and nanoscale systems, -omics, sensing, separations, spectroscopy, and surface analysis. Papers dealing with established analytical methods need to offer a significantly improved, original application of the method. Research manuscripts include Letters, Technical Notes and Articles. The maximum lengths of Letters, Technical Notes and articles are four, five and eight journal pages, respectively. In addition, the journal publishes Features, Perspectives, and Reviews. Feature articles are written for the generalist and are intended to broaden readers’ professional interests and keep them aware of the role of analytical chemistry in the scientific arena. Perspectives point out the authors’ vision of the character and importance of a new direction in analytical chemistry, analyze research reports that provide the foundation for the new direction, and discuss the nature of the opportunities perceived. Reviews are invited and highlight recent advances in a specific subfield of measurement science. See our author guidelines for more information on the journal, the manuscript types, and how to estimate paper length.