个人简述:

张景海，男，博士，教授，医疗器械学院院长。1983年毕业于南京大学生物系生物化学专业，同年任教于沈阳药科大学生物化学教研室。在南京大学生命科学院生物化学系―医药生物技术国家重点实验室毕业并获生化与分子生物学理学博士学位。在沈阳药科大学药学博士后工作站从事药学科研工作两年。任教以来，承担本科生《生物化学》理论及实验、硕士研究生《生物大分子分离纯化及检测》理论及实验。先后主持承担“国家科技部重大新药创制课题”、“国家自然科学基金”、“国家科技攻关”、“中国博士后科学基金”、“霍英东教育基金会―高等院校青年教师基金”、“省市重点科研、自然科学基金”等课题二十余项。在国内外期刊等发表八十余篇论文，其中三十余篇是SCI收录的杂志。出版各类教材、专著十本，如，人民卫生出版社出版的全国高等医药院校教材《生物化学》、《药学分子生物学》，中国医药科技出版社出版的《生物化学实验》，现代药学高级丛书《实用生物制药学》。申请中国发明专利近二十项。

科研工作:

近年来发表代表性论文：1.Meng X, Xu Y, Wang F, Zhao M*, Hou X, Ma Y, Jin Y, Liu Y, Song Y, Zhang J*. 2017. The Roles of Conserved Aromatic Residues (Tyr5 and Tyr42) in Interaction of Scorpion Toxin BmK AGP-SYPU1 with Human Nav1.7. Int J Biol Macromol. doi: 10.1016/j.ijbiomac.2017.01.020Daihua Wen, XialuWang, Lei Shang, Yu Huan, Tienan Li, Chunfu Wu, Rong Zhang, Jinghai Zhang*. Involvement of a versatile pattern recognition receptor, apolipophorin-III in prophenoloxidase activation and antibacterial defense of Chinese oak silkworm, Antheraea pernyi. Developmental & Comparative Immunology, 2016, 4(65):124-1312.Yiren Wang, Yuting Cui, Fayang Cao, Yiyang Qin, Wenjing Li, Jinghai Zhang*. Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-κB signaling pathways through TLR4. International Immunopharmacology, 2015, 28:136-1453.Meng X, Xu Y, Zhao M, Wang F, Ma Y, Jin Y, Liu Y, Song Y, Zhang J*. The Functional Property Changes of Muscular Nav1.4 and Cardiac Nav1.5 Induced by Scorpion Toxin BmK AGP-SYPU1 Mutants Y42F and Y5F. Biochemistry, 2015, 54(19):2988-29964.Guang-Ying Du, Hai-Bo Zhu, Peng-Fei Yu, Hong-Bo Wang, Jie He, Liang Ye, Feng-Hua Fu, Jing-Hai Zhang*, Jing-Wei Tian. SMND-309 promotes angiogenesis in human umbilical vein endothelial cells through activating erythropoietin receptor/STAT3/VEGF pathways, European Journal of Pharmacology, 2013, 700(1-3):173-1805.Yueqiu Wang, Zhihui Hao, Jianhua Shao, et al. The role of Ser54 in the antinociceptive activity of BmK9, a neurotoxin from the scorpion Buthus martensii Karsch, Toxicon, 2011, 58(6-7): 527-5326.Qian Liu, Yao Jin, Kung Wang, Xiang-xue Meng, Yang Yang, Zhuo Yang, Yong-shan Zhao, Ming-yi Zhao, Jing-hai Zhang*. Study of the binding residues between β1 and β3 subunits of sodium channel, CRB, 2014, 337(2):73-777.Jian-hua Shao, Yong Cui, Ming-yi Zhao, Yan-feng Liu*, Chun-fu Wu, Jing-hai Zhang**. Purification, characterization, and bioactivity of a new analgesic-antitumor peptide from Chinese scorpion Buthus martensii Karsch, Peptides, 20148.Yong-shan Zhao, Rong Zhang, Yang Xu, Yong Cui, Yan-feng Liu, Yong-bo Song, Hong-xing Zhang, Jing-hai Zhang*. The role of glycine residues at the C-terminal peptide segment in antinociceptive activity: a molecular dynamics simulation, J Mol Model, 2013, 19: 1295-12999.Yu Wang, Yong-bo Song, Guang-zhao Yang, Yong Cui, Yong-shan Zhao, Yan-feng Liu, Yan Ma, Chun-fu Wu, Jing-hai Zhang. Arginine Residues in the C-terminal and their Relationship with the Analgesic Activity of the Toxin from the Chinese Scorpion Buthus martensii Karsch (BmK AGP-SYPU1), Appl Biochem Biotechnol, 2012 Sep168(2):247-255