个人简述:

本人一直从事基因表达调控、细胞信号传导及肿瘤发生分子机制的研究，深入探讨了miRNA功能网络在调控肝纤维化、肝癌增殖、凋亡、转移等过程中的作用以及血液循环miRNA在肝癌早期诊断中的应用，在国际期刊Lancet Oncology、Hepatology、Oncogene、Nucleic Acids Research、Clinical Cancer Research、Cancer Letters等杂志发表论文11篇，影响因子均>5，其中第一共同第一、共同通讯作者4篇，一篇文章被Faculty of 1000推荐阅读，h因子9。

科研工作:

1. Zeng C, Wang R, Li D, Lin XJ, Wei QK, Yuan Y, Wang Q, Chen W, Zhuang SM*. A novel GSK-3 beta-CEBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma. Hepatology, 2010,52:1702-12. (IF: 13.2 Recommended Article by the Faculty of 1000 Biology)2. Zhang JP, Zeng C, Xu L, Gong J, Fang JH, Zhuang SM*. MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting c-Metsnail signaling. Oncogene, 2014,33(31):4069-76. (IF: 7.5, co-first author)3. Zeng C, Wang YL, Xie C, Sang Y, Li TJ, Zhang M, Wang RZ, Zhang Q, Zheng L, Zhuang SM*. Identification of a novel TGF-？-miR-122-fibronectin 1serum response factor signaling cascade and its implication in hepatic fibrogenesis. Oncotarget, 2015,6(14):12224-33. (IF: 5.1)4. Li X, Li J, Cai Y, Peng S, Wang J, Xiao Z, Wang Y, Tao Y, Li J, Leng Q, Wu D, Yang S, Ji Z, Han Y, Li L, Gao X, Zeng C*, Wen X*. Hyperglycaemia-induced miR-301a promotes cell proliferation by repressing p21 and Smad4 in prostate cancer. Cancer Lett, 2018,418:211-220. (IF: 6.3, co-corresponding author)5. Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, Huang X, Zhang JP, Guan XY, Zhuang SM*. MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology, 2011,54:1729-40. (IF: 13.2)6. Zhu Y, Lu Y, Zhang Q, Liu JJ, Li TJ, Yang JR, Zeng C, Zhuang SM*. MicroRNA-26ab and their host genes cooperate to inhibit the G1S transition by activating the pRb protein. Nucleic Acids Res, 2012,40:4615-25. (IF: 10.1)7. Gong J, Zhang JP, Li B, Zeng C, You K, Chen MX, Yuan Y*, Zhuang SM*. MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene, 2013,32:3071-9. (IF: 7.5)