个人简述:

苏仁伟，1984年1月生于黑龙江省北安市，华南农业大学兽医学院教授（首聘），硕士生导师。

十多年来长期从事雌性哺乳动物生殖与发育，及妇产科疾病机理研究。在PNAS等SCI杂志上发表多篇论文，总引用次数超过300次。近年来主要关注和研究Notch信号通路在雌性哺乳动物胚胎着床、蜕膜化和生殖生理、病理方面的作用。目前从事雌性哺乳类子宫腺体发育方面的研究。研究方法包括原代细胞培养、基因工程小鼠和其他细胞、分子生物学手段。

科研工作:

工作经历
2016年11月至今：首聘教授，华南农业大学兽医学院

2011年8月2016年10月：博士后，美国密歇根州立大学医学院妇产科及生殖生物学系(DepartmentofOB/GYN&ReproBiol,MichiganStateUniversity)
科研项目
国家自然科学基金面上项目《Notch信号通路对小鼠子宫腺体发生和发育的影响》，60万元。
发表论文
1.StrugMR,SuR,YoungJE,DoddsWG,ShavellVI,Díaz-GimenoP,Ruíz-AlonsoM,SimónC,LesseyBA,LeachRE,FazleabasAT.Intrauterinehumanchorionicgonadotropininfusioninoocytedonorspromotesendometrialsynchronyandinductionofearlydecidualmarkersforstromalsurvival:arandomizedclinicaltrial.HumanReproduction.201631(7):1552-61.

2.SuRW*,StrugMR,MieleL,JeongJW,FazleabasAT.AberrantactivationofcanonicalNotch1signalinginthemouseuterusdecreasesprogesteronereceptorbyhypermethylationandleadstoinfertility.ProcNatlAcadSciUSA.2016Feb23113(8):2300-5.

3.SuRW*,FazleabasAT.ImplantationandEstablishmentofPregnancyinHumanandnon-humanPrimates.Chapter10in“RegulationofImplantationandEstablishmentofPregnancyinMammals”Eds.GeisertRDandBazerFW.ISBN:978-3-319-15855-6.AdvAnatEmbryolCellBiol.2015216:189-213.

4.JoshiNR,SuRW,KhooSK,JeongJW,YoungSL,LesseyBA,FazleabasAT.Alterede­xpressionofmicroRNAs(miR)ineutopicendometriumofbaboons(Papioanubis)followingtheinductionofendometriosis.HumReprod.2015Sep14.pii:dev229.

5.SuRW*,StrugMR,JoshiNR,JeongJW,MieleL,LesseyBA,YoungSL,FazleabasAT.DecreasedNotchpathwaysignalingintheendometriumofwomenwithendometriosisimpairsdecidualization.JClinEndocrinolMetab.2015100(3):E433-42.

6.SuRW*,JiaB,NiH,LeiW,YueSL,FengXH,DengWB,LiuJL,ZhaoZA,WangTS,YangZM.Junctionaladhesionmolecule2mediatestheinteractionbetweenhatchedblastocystandluminalepithelium:inductionbyprogesteroneandLIF.PLoSOne.20127(4):e34325.

7.LiuJL,LiangXH,SuRW,LeiW,JiaB,FengXH,LiZX,YangZM.2011.ThecombinedanalysisofmicroRNomeand3’-UTRomerevealsaspecies-specificregulationofprogesteronereceptore­xpressionintheendometriumofrhesusmonkey.JournalofBiologicalChemistry.2012Apr20287(17):13899-910.

8.LeiW,FengXH,NiH,ZhangZR,JiaB,DengWB,YangXL,WangTS,LiuJL,SuRW,YangZM.2011.ProgesteroneencouragesuterinecellproliferationanddecidualizationthroughupregulatingRibonucleotideReductase2e­xpressionduringearlypregnancyinmice.JournalofBiologicalChemistry.2012May4287(19):15174-92.

9.LiuJL,SuRW,YangZM.Differentiale­xpressionprofilesofmRNAs,miRNAsandproteinsduringembryoimplantation.FrontBiosci(ScholEd).20113:1511-9.

10.ShaAG,LiuJL,JiangXM,RenJZ,MaCH,LeiW,SuRW,YangZM.Genome-wideidentificationofmicro-ribonucleicacidsassociatedwithhumanendometrialreceptivityinnaturalandstimulatedcyclesbydeepsequencing.FertilSteril.201196(1):150-155.e5.

11.SuRW*,LeiW*,LiuJL,ZhangZR,JiaB,FengXH,RenG,HuSJ,YangZM.TheintegrativeanalysisofmicroRNAandmRNAe­xpressioninmouseuterusunderdelayedimplantationandactivation.PLoSOne.20105(11):e15513.(*EqualContributionAuthors).

12.LiangXH,ZhaoZA,DengWB,TianZ,LeiW,XuX,ZhangXH,SuRW,YangZM.2010.EstrogenRegulatesAmiloride-BindingProtein1throughCCAAT/Enhancer-BindingProtein-{beta}inMouseUterusduringEmbryoImplantationandDecidualization.Endocrinology,Jul28.

13.SuRW,SunZG,ZhaoYC,ChenQJ,YangZM,LiRS,WangJ.Theuterinee­xpressionofSEC63geneisup-regulatedatimplantationsitesinassociationwiththedecidualizationduringtheearlypregnancyinmice.ReprodBiolEndocrinol.20097:12.

14.SunZG,SuRW,YangZM,ShiHJ,LiuCQ,WangJ.Expressionofthenovelgeneembryoimplantationfactor2(EMO2)inthemouseuterusattheimplantationsites.FertilSteril.200991:2116-22.

15.DiaoHL,SuRW,TanHN,LiSJ,LeiW,DengWB,YangZM.Effectsofandrogenonembryoimplantationinthemousedelayed-implantationmodel.FertilSteril.200890:1376-83.

16.HuSJ,RenG,LiuJL,ZhaoZA,YuYS,SuRW,MaXH,NiH,LeiW,YangZM.MicroRNAe­xpressionandregulationinmouseuterusduringembryoimplantation.JBiolChem.2008283(34):23473-84.

17.ZhaoYC,ChiYJ,YuYS,LiuJL,SuRW,MaXH,ShanCH,YangZM.Polyaminesareessentialinembryoimplantation:e­xpressionandfunctionofpolyamine-relatedgenesinmouseuterusduringperi-implantationperiod.Endocrinology.2008149(5):2325-32.

18.DiaoHL,ZhuH,MaH,TanHN,CongJ,SuRW,YangZM.Ratovulation,implantationanddecidualizationareseverelycompromisedbyCOX-2inhibitors.FrontBiosci.200712:3333-42.

教育背景:

2012年4月至6月：生殖前沿课程及实验技能培训(FrontiersinReproduction,FIR)，美国马里兰州海洋生物研究所(MarineBiologicalLaboratory,WoodsHole,MA,USA)

2005年9月至2010年6月：基础兽医学博士，东北农业大学兽医学院

2001年9月至2005年6月：理学学士，东北农业大学生命科学学院理科基地班