个人简述:

胚胎植入的分子机制和抗着床药物先导分子的筛选促进人口和计划生育科学技术进步作出重大贡献的优秀科技成果二等奖2011-06-01排名4

科研工作:

工作经历
2009-07-01至2013-09-01厦门大学生命科学学院博士后
2013-07-01至今华南农业大学兽医学院讲师
科研项目
1.国家自然科学基金青年项目，31501206、Snail在着床、内膜重建、异位症中的功能及作用机制、2016/1-2018/12、20万元、正在进行、主持。
2.中国博士后基金，2011M501080、早期生长反应因子1在小鼠胚胎着床过程子宫中的表达与调节、2011/11-2013/9、3万元、结题、主持。
3.国家自然科学基金面上项目，31471397、多胺与小鼠胚胎着床及蜕膜化的关系、2015/01-2018/12、85万元、正在进行、参加（排名2）。
4.国家自然科学基金面上项目，31471398、let-7调节胚胎休眠的作用机理、2015/01-2018/12、85万元、正在进行、参加（排名4）。
5.国家自然科学基金重点项目，309300113、小鼠胚胎着床过程中信号转导和转录激活因子3的作用机理、2010/01-2013/12、191万元、结题、参加（排名3）。
发表论文
1.LiangXH,DengWB,LiuYF,LiangYX,FanZM,GuXW,LiuJL,ShaAG,DiaoHL,YangZM,2016.Non-codingRNALINC00473mediatesdecidualizationofhumanendometrialstromalcellsinresponsetocAMPsignaling.SciRep6:22744.
2.LiangXH,DengWB,LiM,ZhaoZA,WangTS,FengXH,CaoYJ,DuanEK,YangZM,2014.Egr1proteinactsdownstreamofestrogen-Leukemiainhibitoryfactor(LIF)-STAT3pathwayandplaysaroleduringimplantationthroughtargetingWnt4.JBiolChem289:23534-23545.
3.LiangXH,ZhaoZA,DengWB,TianZ,LeiW,XuX,ZhangXH,SuRW,YangZM,2010.Estrogenregulatesamiloride-bindingprotein1throughCCAAT/enhancer-bindingprotein-inmouseuterusduringembryoimplantationanddecidualization.Endocrinology151:5007-5016.
4.LiuJL*,LiangXH*（共同第一作者）,SuRW,LeiW,JiaB,FengXH,LiZX,YangZM,2012.ThecombinedanalysisofmicroRNomeand3'-UTRomerevealsaspecies-specificregulationofprogesteronereceptorexpressionintheendometriumofrhesusmonkey.JBiolChem.2012Feb29.287(17):13899-910.
5.DengWB,LiangXH,LiuJL,YangZM,2014.Regulationandfunctionofdeiodinasesduringdecidualizationinfemalemice.Endocrinology.155:2704-17.
6.RengarajD,LiangXH,GaoF,DengWB,MillsN,YangZM,2008.Differentialexpressionandregulationofintegralmembraneprotein2binratmalereproductivetissues.AsianJAndrol.10:503-501.
7.RengarajD,HwangYS,LiangXH,DengWB,YangZM,HanJY.ComparativeexpressionandregulationofTMSB4Xinmalereproductivetissuesofratsandchickens.JExpZoolAEcolGenetPhysiol.2013Dec319(10):584-95.
8.DengWB,TianZ,LiangXH,WangBC,YangF,YangZM,2013.ProgesteroneregulationofNa/K-ATPaseβ1subunitexpressioninthemouseuterusduringtheperi-implantationperiod.Theriogenology79(8):1196-203.
9.ZhangXH,LiangX,LiangXH,WangTS,QiQR,DengWB,ShaAG,YangZM,2013.Themesenchymal-epithelialtransitionduringinvitrodecidualization.ReprodSci.20(4):354-60.
10.TianZ,ZhaoZA,LiangXH,ZhangXH,ShaAG,ZhangZR,YuYS,YangZM,2011.Expressionandfunctionoffattyacid-bindingprotein4duringmousedecidualization.FertilSteril.95(8):2749-2752.
11.RengarajD,GaoF,LiangXH,YangZM,2007.ExpressionandregulationoftypeIIintegralmembraneproteinfamilymembersinmousemalereproductivetissues.Endocrine31:193-201.
12.ZhangXH,LiangX,WangTS,LiangXH,ZuoRJ,DengWB,ZhangZR,QinFN,ZhaoZA,YangZM,2013.Heparin-bindingepidermalgrowthfactor-likegrowthfactor(HB-EGF)inductiononSnailexpressionduringmousedecidualization.MolCellEndocrinol.381(1-2):272-279.
13.HuangZ,WangTS,QiQR,ZuoRJ,LiangXH,ZhaoXY,YangZM,2014.Progesteroneregulatessecretinexpressioninmouseuterusduringearlypregnancy.ReprodSci.21(6):724-32.
14.XuX,LengJY,GaoF,ZhaoZA,DengWB,LiangXH,ZhangYJ,ZhangZR,LiM,ShaAG,YangZM,2014.Differentialexpressionandanti-oxidantfunctionofglutathioneperoxidase3inmouseuterusduringdecidualization.FEBSLett.588(9):1580-9.
15.ZhaoZA,ZhangZR,XuX,DengWB,LiM,LengJY,LiangXH,YangZM,2012.ArachidonicacidregulationoncPLA2α/COX-2pathwayinmouseendometrialstromalcells.Fertility&Sterility97(5):1199-1205.
16.MaXH,HuSJ,NiH,ZhaoYC,TianZ,LiuJL,RenG,LiangXH,YuH,WanP,YangZM,2006.Serialanalysisofgeneexpressioninmouseuterusattheimplantationsite.JBiolChem.281:9351-9360.
17.LeiW,FengXH,DengWB,NiH,ZhangZR,JiaB,YangXL,WangTS,LiuJL,SuRW,LiangXH,QiQR,YangZM,2012.ProgesteroneandDNAdamageencourageuterinecellproliferationanddecidualizationthroughupregulatingribonucleotidereductase2expressionduringearlypregnancyinmice.JBiolChem.287(19):15174-92.

教育背景:

2000-09-01至2004-07-01东北农业大学生命科学学院生物科学本科学士杨增明教授
2004-09-01至2009-07-01东北农业大学生命科学学院基础兽医学博士博士杨增明教授