个人简述:

运用电生理学技术，结合分子与细胞生物学等研究手段，开展靶向KCNQ、HCN和VRAC等离子通道的药物发现和机制研究。研究关注与细胞电活动异常相关的人类疾病，如疼痛、心衰等。

科研工作:

1. Zhou, P.*, Zhang, Y.*, Xu, H., Chen, F., Chen, X., Li, X., Pi, X., Wang, L., Zhan L., Nan, F., and Gao, Z. (2015) P-Retigabine: a N-propargyled retigbaine with improved brain distrubution and enhanced antiepileptic activity. Molecular Pharmacology 87 (1), 31-8. 2. Zhou, P., Yu, H., Gu, M., Nan, F.J., Gao, Z., and Li, M. (2013). Phosphatidylinositol 4,5 -bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Proc Natl Acad Sci U S A 110, 8726-8731. 3. Zhang, Q. *, Zhou, P. *, Chen, Z., Li, M., Jiang, H., Gao, Z., Yang, Y. (2013) Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating. Proc Natl Acad Sci U S A 110(50):20093-8.