个人简述:

肖易倍（Yibei Xiao）, 博士。中国药科大学教授，博士生导师。2018年入选中组部第十四批“青年千人计划”，并获得优先资助。同年作为海外高层次引进人才回到中国药科大学。主要利用生物化学，微生物学，药物设计学，和生物物理学等多学科结合研究思路与方法，研究细菌的获得性免疫防御系统（CRISPR-Cas）的分子作用机制，RNA病毒的转录复制机制以及抗病毒药物的开发。近三年已在Science, Nature和Cell杂志以第一作者发表论文四篇，共同作者发表两篇。

科研工作:

近五年代表性论文：1. Xiao, Y., Luo, M., AE Dolan., Liao, M., Ke, A. (2018). Structure Basis for RNA-guided DNA degradation by Cascade and Cas3 in Type I-E CRISPR-Cas system. Science, (accepted).2. Xiao, Y., Ng, S., Nam, KH., & Ke. A. (2017). How Type II CRISPR-Cas establishes immunity through Cas1-Cas2 mediated spacer integration. Nature, 550 (7674), 137.3. Xiao, Y., Luo, M.,Hayes, R. P., Kim, J., Ng, S., Ding, F., Liao, M., Ke, A. (2017). Structure basis for directional R-loop formation and substrate handover mechanisms in Type I CRISPR-Cas system. Cell, 170(1), 48-60.4. MW Brown., KE Dillard., Y Xiao., AE Dolan., ET Hernandez., S Dahlhauser., …& Finkelstein, I. (2017).Assembly and translocation of a CRISPR-Cas primed acquisition complex. bioRxiv, 208058.5. Jung, C., Hawkins, J., Jones Jr, S., Xiao, Y., … Ke, A., & Finkelstein, I. (2017). Massively parallel biophysical analysis of a CRISPR-Cas protein complex on repurposed next generation sequencing chips. Cell, 170(1), 35-47.6. Xiao, Y. and Ke, A., (2016). PIWI Takes a Giant Step.Cell,167(2), 310-312.7. Hayes, R. P., Xiao, Y., Ding, F., Van Erp, P. B., Rajashankar, K., Bailey, S., ... & Ke, A. (2016). Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli. Nature, 530(7591), 499-503.8. Qin, Z., Xiao, Y., Yang, X., Mesters, J. R., Yang, S., & Jiang, Z. (2015). A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 β-N-acetylglucosaminidase. Scientific reports, 5.9. Huo, Y., Nam, K. H., Ding, F., Lee, H., Wu, L., Xiao, Y., ... & Ke, A. (2014). Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation. Nature structural & molecular biology, 21(9), 771-777.10. Xiao, Y., Ma, Q., Restle, T., Shang, W., Svergun, D.I., Ponnusamy, R., ... & Hilgenfeld, R. (2012). Nonstructural proteins 7 and 8 of feline coronavirus form a 2: 1 heterotrimer that exhibits primer-independent RNA polymerase activity. Journal of Virology, 86(8), 4444-4454.

教育背景:

02.2014 – 03.2018 (博士后): Department of Molecular Biology and Genetics, Cornell University, 美国。08.2008 - 01.2014 (博士): Institut für Biochemie, Universität zu Lübeck, 德国。09.2006 - 06.2008 (硕士): 武汉大学, 生命科学学院。09.2002 - 07.2006 (本科): 中国药科大学, 生命科学与技术人才培养基地。