个人简述:

肠道微生物是机体疾病调控的核心因素，已有众多报道表明它可以参与各主要外周器官损伤的进程，但其中的机制还不十分清楚。我们课题组将围绕脓毒症相关MODS及药（毒）物性器官损伤两个方向开展基础与转化研究。我们将运用各种针对肠道微生物的组学分析结合动物、细胞水平的基础实验挖掘干预器官损伤的新分子、新靶点，为临床上防治多器官功能衰竭提供新的理论基础和指导。

科研工作:

1、Gong S#, Lan T#, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y*, Kaplowitz N, Chen P*. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul69(1):51-59. (IF: 14.91)2、Hu J#, Luo H, Wang J, Tang W, Lu J, Wu S, Xiong Z, Yang G, Chen Z, Lan T, Zhou H, Nie J, Jiang Y, Chen P*. Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice. Exp Mol Med. 201749(8):e370. (IF: 5.58)3、Chen P#, St？rkel P, Turner JR, Ho SB, Schnabl B*. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology. 201561(3):883-894. (IF: 14.08)4、Chen P#, Torralba M, Tan J, Embree M, Zengler K, St？rkel P, van Pijkeren JP, DePew J, Loomba R, Ho SB, Bajaj JS, Mutlu EA, Keshavarzian A, Tsukamoto H, Nelson KE, Fouts DE, Schnabl B*. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology. 2015148(1):203-214. (IF: 20.77)