个人简述:

男，汉族，1979年9月生，河南省罗山县人，博士、副教授，河南理工大学资源环境学院生物系硕士生导师。

科研工作:

科研情况:
        1. 主持的科研项目2012年10月-2014年9月，G-四链体核酸的抗肿瘤增殖活性研究，北京分子科学国家实验室开放基金课题，5万元；2013年1月-2016年12月，基于核酸适配体的金黄色葡萄球菌及其肠毒素的分析方法研究，河南理工大学博士基金，6万元；2013年1月-2014年12月，G-四链体核酸的抗肿瘤增殖活性研究，河南省教育厅科学技术研究重点项目，2万元；2014年1月-2015年12月，G-四链体自组装结构的多态性及影响因素研究，河南理工大学青年骨干教师项目，1万元；2. 科研获奖2013年10月，作为主要完成人，获得中国分析测试协会科学技术奖一等奖（2013-1-002-R）。论文情况:
      [1] Tianjun Chang*, Gang Li, Kexu Zhao, Lin Ban, Wenxiu Bian, Tao Bing, Dihua Shangguan*. Effect of Loops, Flanking Bases and Monovalent Cations on the Structures of G-quadruplexes. Chem. J. Chinese Universities-Chinese, 2014. Accepted (SCI, correspondence author)[2] Tianjun Chang, Cui Qi, Jie Meng, Nan Zhang, Tao Bing, Xianda Yang, Zehui Cao, Dihua Shangguan*. General Cell-Binding Activity of Intramolecular G-Quadruplexes with Parallel Structure. PLOS ONE, 8(4): e62348, 2013 （SCI）[3] Tianjun Chang, Xiangjun Liu, Xiaohong Cheng, Cui Qi, Hongcheng Mei, Dihua Shangguan*. Selective isolation of G-quadruplexes by affinity chromatography. J Chromatogr A. 1246, pp 62, 2012 （SCI）[4] Hongcheng Mei, Tao Bing, Cui Qi, Nan Zhang, Xiangjun Liu, Tianjun Chang, Jingli Yan, Dihua Shangguan*. Rational design of Hg2+ controlled streptavidin-binding aptamer. Chem Commun (Camb), 49 (2), pp 164, 2013（SCI）[5] Jin Zhou, Canliang Fang, Tianjun Chang, Xiangjun Liu，Dihua Shangguan*. A pH sensitive ratiometric fluorophore and its application for monitoring the intracellular and extracellular pHs simultaneously. J Mater Chem B, 1, pp 661, 2013（SCI）[6] Xiangjun Liu, Nan Zhang, Jin Zhou, Tianjun Chang, Canliang Fang, Dihua Shangguan*. A turn-on fluorescent sensor for zinc and cadmium ions based on perylene tetracarboxylic diimide. Analyst, 138 (3), pp 901, 2013（SCI）[7] Hongcheng Mei, Tao Bing, Xiaojuan Yang, Cui Qi, Tianjun Chang, Xiangjun Liu, Zehui Cao, Dihua Shangguan*. Functional-group specific aptamers indirectly recognizing compounds with alkyl amino group. Anal Chem, 84 (17), pp 7323, 2012 （SCI）[8] Tao Bing, Tianjun Chang, Cui Qi, Nan Zhang, Xiangjun Liu, Dihua Shangguan*. Specific interactions between adenosine and streptavidin/avidin. Bioorg Med Chem Lett, 22 (23), pp 7052, 2012 （SCI）[9] Tao Bing, Tianjun Chang, Xiaojuan Yang, Hongcheng Mei, Xiangjun Liu, Dihua Shangguan*. G-quadruplex DNA aptamers generated for systemin. Bioorg Med Chem, 19 (14), pp 4211, 2011（SCI）[10] Xiaojuan Yang, Canliang Fang, Hongcheng Mei, Tianjun Chang, Zehui Cao, Dihua Shangguan*. Characterization of G-quadruplex/hemin peroxidase: substrate specificity and inactivation kinetics. Chem-Eur J, 17 (51), pp 14475, 2011（SCI）[11] 常天俊*，李刚，李卫国. G-四链体核酸的生物学功能，生命的化学, 2014, 34(3): pp 385