个人简述:

王淑珍，女，1982年生。江苏省“333”工程第三层次、江苏省六大人才高峰资助计划获得者。现为中国药科大学生命科学与技术学院化学生物学研究室副教授、博士生导师，主要从事抗肿瘤分子靶向创新药物方面的研究。迄今共发表学术论文10余篇，申请PCT和中国发明专利8项，授权3项。现主持国家自然科学基金面上项目1项，先后参与“重大新药创制”国家科技重大专项项目、国家自然科学基金项目和江苏省科技支撑计划项目等多项国家和省级课题。

科研工作:

代表性论文：1.Wang, S.Z., Zheng, X.L., Pan, Q. & Chen, Y.J.* Mutagenesis of precursor peptide for the generation of nosiheptide analogues. RSC Adv., 2016, 6, 94643-94650.2.Wang, S.Z., Xie, W.Q., Wang, D.W., Peng, Z.G., Zheng, Y., Liu, N., Dai, W., Wang, Y., Wang, Z.Q., Yang, Y.* & Chen, Y.J.* Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia. Oncotarget. 2015, 6(14), 12128-12140.3.Ma, M., Xue, Y.J., Liu, W.Y., Zhang, H., Kong, L.Y., Wang, S.Z.*, Chen, Y.J.* Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide. Chem. Commun. 2014, 50 (72), 10430-10433.4.Liu, W.Y., Ma, M., Xue, Y.J., Liu, N., Wang, S.Z.*, Chen, Y.J.* The C-terminal extended serine residue is absolutely required in nosiheptide maturation. ChemBioChem. 2013, 14(5), 573-576.5.Feng, K., Wang, S.Z., Ma, H.R., Chen, Y.J.* Chirality plays critical roles in enhancing the aqueous solubility of nocathiacin I by block copolymer micelles. J. Pharm. Pharmcol. 2013, 65(1), 64-71.6.Ju, J.M., Qi, Z.C., Cai, X.T., Cao, P., Liu, N., Wang, S.Z.*, Chen, Y.J.* Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells. Toxicol. In Vitro. 2013, 27(1), 232-238.7.Wang, S.Z., Lv, J.F., Wang, P., Yin, X.J., Tan, A.M. & Chen, Y.J.* Recombinant human CD137L for cancer immunotherapy: effects of different fusions and linkers on its activity. Cancer Immunol. Immunother. 2012, 61(4):489-495.8.Wang, S.Z., Tan, A.M., Lv, J.F., Wang, P., Yin, X.J. & Chen, Y.J.* Soluble expression of recombinant human CD137 ligand in Escherichia coli by co-expression of chaperones. J. Ind. Microbiol. Biotechnol. 2012, 39(3), 471-476.

教育背景:

2002年毕业于聊城大学，获得生物科学专业学士学位；2005年获南京师范大学细胞生物学专业硕士学位；2008年获中国药科大学微生物与生化药学专业博士学位。