个人简述:

郭薇，女，博士，江苏扬州人，副教授，硕士生导师，科研方向主要为生物技术以及抗体类药物的研发,参加国家863重大专项，十二五新药研制等多个科研项目，在分子修饰、免疫学相关分析技术以及生物药物研制方面积累了较丰富的经验。入选江苏省第十一批次“六大人才高峰”，获得上海复星医药奖教金，江苏省生物化学与分子生物学青年教师授课比赛一等奖，“药学的生物化学基础”国家级精品资源共享课（2013年度），编写教材《药学分子生物学》、《生物化学》、《药学细胞生物学》。

科研工作:

SCI文章及专利：1、Wei Guo, Dongmei Yu, Xin Wang, Cheng Luo, Yucong Chen, Wen Lei, Chen Wang, Yaoyao Ge, Wenyao Xue, Qiqi Tian, Xiangdong Gao*, Wenbing Yao*. Anti-inflammatory effects of Interleukin-23 receptor cytokine-binding homology region rebalance T cell distribution in rodentcollagen-induced arthritis. Oncotarget. 2016, doi: 10.18632/.9309.2、Wei Guo, Chen Wang, Xin Wang, Cheng Luo, Dongmei Yu, Yuheng Wang, Yucong Chen, Wen Lei, Xiangdong Gao*, Wenbing Yao*. A novel human truncated IL12rβ1-Fc fusion protein ameliorates experimental autoimmune encephalomyelitis via specific binding of p40 to inhibit Th1 and Th17 cell differentiation. Oncotarget, 2015, 6(30):28539-28555.3、Wei Guo，Cheng Luo，Chen Wang，Yu heng Wang，Xin Wang，Xiang dong Gao，Wen Bing Yao，Suppression of human and mouse Th17 differentiation and autoimmunity by an endogenous Interleukin 23 receptor cytokine-binding homology region，International Journal of Biochemistry & Cell Biolog,2014,55:304-310.4、Wei Guo, Cheng Luo, Chen Wang, Yue Zhu, Xin Wang, Xiangdong Gao*, WenbingYao*. Protection against Th17 Cells Differentiation by Interleukin-23 Receptor HomologyRegion. PLoS ONE, 2012, e45625.5、Chen Wang, Wei Guo, Di Cai, Xin Wang, Dongmei Yu, Xiangdong Gao*, WenbingYao*. A truncated IL-12rβ1 receptor ameliorates chronic graft-versus-host disease-induced lupus nephritis by inhibiting Th1 and Th17 cells. Int Immunopharmacol. 2015 Dec29(2):544-51.6、Gao M, Tian H, Ma C, Gao X, Guo Wei, Yao W Expression, Purification, and C-terminal Site-Specific PEGylation of Cysteine-Mutated Glucagon-Like Peptide-1.Applied Biochemistry and Biotechnology, 2010 162(9):155-165.7、Chuanlai Shen, Chien-Chung Chang, Jianqiong Zhang, Guowei, Fanyan MENG and Wei Xie.Structural and functional characterization of peptide-beta(2)m fused HLA-A2/MART1(27-35) complexes. Biochem Biophy Res Commun 2006 Mar 31342(1):57-65.8、Fanyan Meng, Jianqiong Zhang，Chuanlai Shen, Wei Guo, Wei Xie. One-step to generate MHC-peptide complexes using immobilized metal affinity chromatography (IMAC). Tissue Antigens. 2007, 69(5):405.9、Chuanlai Shen, Chien-Chung Chang, Jianqiong Zhang, Guowei, Fanyan MENG and Wei Xie.Generation of a HLA-A2/MART127-35 tetramer with peptide -linked β2 microglobulin J Microbiol Immunol, Vol 2, No. 4, November, 2004,286-29410、Guo Wei，Ni Guangxia. The effects of acupuncture on blood pressure in different patients. Journal of Traditional Chinese Medicine. 2003,23:49-5011、高向东，郭薇，朱玥，姚文兵，罗成，王辰，重组质粒pET32a-hIL-23R-CHR及其构建表达，中国，ZL:201110096271.8。12、高向东，郭薇，王欣，姚文兵，王辰，郁冬梅，陈语聪，王宇恒，新型IL23拮抗剂，中国，CN:201510071915.6。13、姚文兵，郭薇，王辰，高向东，王欣，郁冬梅，雷雯，一种人IL12Rβ1-CHR蛋白及其Fc融合蛋白，中国，CN:201510066730.6。14、郭薇，王辰，罗成，王宇恒，王欣，高向东，小鼠Th17细胞体外诱导分化条件的研究，药物生物技术，2013，（06）：514-517。15、郭薇，王辰，王宇恒，高向东，可溶性重组人IL23R-CHR在大肠埃希菌中的表达、纯化及活性研究，中国药科大学学报，2013，（06）：583-588。