个人简述:

舒茂，副教授，硕士生导师。2004.09-2006.06，获重庆大学药物化学专业硕士学位；2006.09-2009.06，获得重庆大学生物医学工程专业博士学位。2009.07-，重庆理工大学药学与生物工程学院教师，2013。12-2014.12，美国国家毒理中心（NCTR/FDA）访问学者。在国内外重要刊物如AminoAcids等发表论文30篇，发表论文共被他人引用200余次；授权专利1件；编写著作1部。获得2010年重庆市优秀博士论文奖奖1项。

科研工作:

承担的主要项目

[1]基于非蛋白氨基酸的小分子抗菌肽设计合成及生物效应研究，国家自然科学基金面上项目，2012.1-2015.12，60万，主持。

[2]HPV16型E7抗原CTL表位模拟肽抗HPV感染的实验研究，国家自然科学基金面上项目，2012.1-2015.12，58万，参与。

[1]WangJ,ShuM,WenXR,WangYL,WangYQ,HuY,LinZH:Discoveryofvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorsbyquantitativestructure-activityrelationships,moleculardynamicssimulationandfreeenergycalculation.RscAdvances2016,6(42):35402-35415.

[2]ShuM,ZaiXL,ZhangBN,WangR,LinZH:HypothyroidismSideEffectinPatientsTreatedwithSunitiniborSorafenib:ClinicalandStructuralAnalyses.PlosOne2016,11(1).

[3]ZhangWQ,NgHW,ShuM,LuoH,SuZQ,GeWG,PerkinsR,TongWD,HongHX:Comparinggeneticvariantsdetectedinthe1000genomesprojectwithSNPsdeterminedbytheInternationalHapMapConsortium.JournalofGenetics2015,94(4):731-740.

[4]YuR,WangJ,WangR,LinY,HuY,WangYQ,ShuM,LinZH:CombinedPharmacophoreModeling,3D-QSAR,HomologyModelingandDockingStudiesonCYP11B1Inhibitors.Molecules2015,20(1):1014-1030.

[5]WangYQ,ZhouPP,LinY,ShuM,HuY,XiaQY,LinZH:QuantitativePredictionofClassIMHC/EpitopeBindingAffinityUsingQSARModelingDerivedfromAminoAcidStructuralInformation.CombinatorialChemistryHighThroughputScreening2015,18(1):75-82.

[6]WangJ,ShuM,LinY,HuY,HanYZ,LinZH:HPV16E7CTLEpitopeAntigenPeptideDesignandActivityEvaluation.ProgressinBiochemistryandBiophysics2015,42(12):1119-1127.

[7]NgHW,ShuM,LuoH,YeH,GeWG,PerkinsR,TongWD,HongHX:EstrogenicActivityDataExtractionandinSilicoPredictionShowtheEndocrineDisruptionPotentialofBisphenolAReplacementCompounds.ChemicalResearchinToxicology2015,28(9):1784-1795.

[8]LuoH,DuTT,ZhouP,YangL,MeiH,NgHW,ZhangWQ,ShuM,TongWD,ShiLMetal:MolecularDockingtoIdentifyAssociationsBetweenDrugsandClassIHumanLeukocyteAntigensforPredictingIdiosyncraticDrugReactions.CombinatorialChemistryHighThroughputScreening2015,18(3):296-304.

[9]ZhangWQ,MeehanJ,SuZQ,NgHW,ShuM,LuoH,GeWG,PerkinsR,TongWD,HongHX:Wholegenomesequencingof35individualsprovidesinsightsintothegeneticarchitectureofKoreanpopulation.BmcBioinformatics2014,15.

[10]NgHW,ZhangWQ,ShuM,LuoH,GeWG,PerkinsR,TongWD,HongHX:Competitivemoleculardockingapproachforpredictingestrogenreceptorsubtypealphaagonistsandantagonists.BmcBioinformatics2014,15.

[11]LiXR,ShuM,WangYQ,YuR,YaoS,LinZH:3D-QSARAnalysisonATRProteinKinaseInhibitorsUsingCoMFAandCoMSIA.CurrentComputer-AidedDrugDesign2014,10(4):327-334.

[12]YangWJ,ShuM,WangYQ,WangR,HuY,MengLX,LinZH:3D-QSARanddockingstudiesof3-PyridineheterocyclicderivativesaspotentPI3K/mTORinhibitors.JournalofMolecularStructure2013,1054:107-116.

[13]WangYQ,LinY,ShuM,WangR,HuY,LinZH:ProteasomalcleavagesitepredictionofproteinantigenusingBPneuralnetworkbasedonanewsetofaminoaciddescriptor.JournalofMolecularModeling2013,19(8):3045-3052.

[14]TanW,MeiH,ChaoL,LiuTF,PanXC,ShuM,YangL:CombinedQSARandmoleculedockingstudiesonpredictingP-glycoproteininhibitors.JournalofComputer-AidedMolecularDesign2013,27(12):1067-1073.

[15]ShuM,YuR,ZhangYR,WangJ,YangL,WangL,LinZH:PredictingtheActivityofAntimicrobialPeptideswithAminoAcidTopologicalInformation.MedicinalChemistry2013,9(1):32-44.

[16]JiYJ,ShuM,LinY,WangYQ,WangR,HuY,LinZH:Combined3D-QSARmodelingandmoleculardockingstudyonazacyclesCCR5antagonists.JournalofMolecularStructure2013,1045:35-41.

[17]ShuM,ZhangYR,TianFF,YangL,LinZH:MolecularDockingand3D-QSARResearchofBiphenylCarboxylicAcidMMP-3Inhibitors.ChineseJournalofStructuralChemistry2012,31(3):443-451.

[18]LuoXY,ShuM,WangYQ,LiuJ,YangWJ,LinZH:3D-QSARStudiesofDihydropyrazoleandDihydropyrroleDerivativesasInhibitorsofHumanMitoticKinesinEg5BasedonMolecularDocking.Molecules2012,17(2):2015-2029.

[19]WangXY,WangJ,HuY,LinY,ShuM,WangL,ChengXM,LinZH:PredictingtheActivityofPeptidesBasedonAminoAcidInformation.JournaloftheChineseChemicalSociety2011,58(7):877-883.

[20]WangJ,WangXY,ShuM,WangYQ,LinY,WangL,ChengXM,LinZH:QSARStudyonMHCClassIAAllelesBasedontheNovelParametersofAminoAcids.ProteinandPeptideLetters2011,18(9):956-963.

[21]ShuM,LinZH,ZhangYR,WuYQ,MeiH,JiangYJ:MoleculardynamicssimulationofoseltamivirresistanceinneuraminidaseofavianinfluenzaH5N1virus.JournalofMolecularModeling2011,17(3):587-592.

[22]ShuM,ChengXM,ZhangYR,WangYQ,LinY,WangL,LinZH:PredictingtheActivityofACEInhibitoryPeptideswithaNovelModeofPseudoAminoAcidComposition.ProteinandPeptideLetters2011,18(12):1233-1243.

[23]LinY,LongHX,WangJ,ShuM,WangYQ,WangL,LinZH:QSARStudyonInsectNeuropeptidePotenciesBasedonaNovelSetofParametersofAminoAcidsbyUsingOSC-PLSMethod.InternationalJournalofPeptideResearchandTherapeutics2011,17(3):201-208.

[24]DingYA,LinY,ShuM,WangYQ,WangL,ChengXM,LinZH:QuantitativeStructure-ActivityRelationshipModelforPredictionofProtein-PeptideInteractionBindingAffinitiesbetweenHumanAmphiphysin-1SH3DomainsandTheirPeptideLigands.InternationalJournalofPeptideResearchandTherapeutics2011,17(1):75-79.

[25]YangL,ShuM,MaKW,MeiH,JiangYJ,LiZL:ST-scaleasanovelaminoaciddescriptoranditsapplicationinQSAMofpeptidesandanalogues.AminoAcids2010,38(3):805-816.

[26]CaiJF,OuRY,XuYS,YangL,LinZH,ShuM:ModelingandpredictinginteractionsbetweenthehumanamphiphysinSH3domainsandtheirpeptideligandsbasedonaminoacidinformation.JournalofPeptideScience2010,16(11):627-632.

[27]ZhuWP,YangSB,LiaoLM,TanC,ShuM:StructuralCharacterizationofVolatileComponentsofRosaBanksiaeAitforEstimationandPredictionofTheirLinearRetentionIndicesandRetentionTimes.ChineseJournalofStructuralChemistry2009,28(4):391-396.

[28]ShuM,MeiH,YangSB,LiaoLM,LiZL:StructuralParameterCharacterizationandBioactivitySimulationBasedonPeptideSequence.QsarCombinatorialScience2009,28(1):27-35.

[29]ShuM,JiangYJ,YangL,WuYQ,MeiH,LiZL:Applicationof'HESH'DescriptorsfortheStructure-ActivityRelationshipsofAntimicrobialPeptides.ProteinandPeptideLetters2009,16(2):143-149.

[30]舒茂，林治华，杨力。蛋白质多肽序列表征方法及其应用。西南交通大学出版社，2010年。