个人简述:

刘建辉，教授，硕士生导师。教育部新世纪优秀人才，重庆市科技创新领军人才，重庆色谱学会副理事长，2000.09–2003.06获得大连理工大学生物化工专业博士学位；1997.09–2000.06获重庆大学物理化学专业硕士学位；1993.09–1997.06获重庆工商大学应用化学专业学士学位。在国内外重要刊物如BrainResearch,NeurochemistryInternational,JournalofBiochemistry,NeuroscienceLetter,CNSNeurologicalDisorder-DrugTarget，PLOSONE等发表论文54篇，其中SCI收录45篇，发表论文共被他人引用1200余次；授权专利2件；编写著作或教材3部。获得2009年重庆市技术发明奖三等奖1项(排名第1)。

科研工作:

承担的主要项目

[1].Txnip在京尼平苷拮抗高糖诱导的胰腺β细胞损伤中的作用机制研究(81373459)，国家自然科学基金面上项目，2014.1-2017.12，65万，主持。

[2].京尼平苷激活GLP-1受体的抗氧化作用机制研究(30600813)，国家自然科学基金青年基金项目，2007.1-2009.12，23万，主持。

[3].京尼平苷诱导胰岛素分泌与GLP-1R的相关性研究(30973576)2010.01-2010.12，8万，主持。

[4].GLP-1受体激动剂的药理学机制研究(NCET-07-0913)，教育部新世纪优秀人才支持计划，2008.01-2010.12，60万，主持。

[5].京尼平苷药理学(CSTC,2014cqkjcxljr009)，重庆科技创新领军人才支持计划，2015.01-2017.12，45万，主持。

[6].京尼平苷调节胰腺β细胞胰岛素分泌的分子机制(CSTC,2012JJB10033)，重庆市科委重点项目，2012.01-2014.12,20万，主持。

[7].Klotho启动子激动剂的功能及作用机制研究(CSTC,2007AA5029)，重庆市科技攻关重大项目，2007.01-2010.12,100万，主持人

[8].京尼平苷对胰腺β细胞氧化还原状态的调节及作用机制研究(CSTC,2015jcyjbx0064)，重庆市科委重点项目，2015.01-2017.12,20万，主持。

[9].催化与功能有机分子优秀团队，重庆市教委，2013.01-2015.12,60万，主持。

代表性成果(*,Correspondingauthor)

(1)ZhangYL,YinF*,LiuJH*,LiuZX,ZidichouskiJ.GeniposideattenuatesthephosphorylationoftauproteinincellularandAPP/PS1transgenicmodelofAlzheimer’sdisease.ChemBiolDrugDes201687(3):409-18.

(2)GuoLX,LiuCY,YinF*,LiuJH*.PossibleroleofAMPK/SIRT1signalingonenergybalanceingeniposide-treatedINS-1cells.MedicinalChemistry201687(1):33-38

(3)ZhangYL,LiuJH*.,LiuZX,YinF*.Geniposideattenuatedinsulin-deficiency-inducedaccelerationofβ-amyloidosisintheAPP/PS1transgenicmodelofAlzheimer’sdisease.NeurochemInt201589:7-16.

(4)ZhangYL,XiaZN,LiuJH*,LiuZX,YinF*.Cellsignalingtransductionmechanismsbywhichgeniposideregulatesinsulin-degradingenzymeexpressioninprimaryculturedcorticalneurons.CNSNeurologicalDisorders-DrugTargets201514(3):370-7.

(5)LiuJH*,LiuZX,ZhangYL,YinF*.LeptinsignalingplaysacriticalroleongeniposideamelioratingthephosphorylationoftauincellularandAPP/PS1transgenicmice.ActaBiochiBiophySin201547(12):1018-22.

(6)LiuJH*,LiuZX,ZhangYL,YinF.Anovelantagonisticroleofnaturalcompoundicariinonneurotoxicityofamyloidβpeptide.IndianJournalMedRes2015142:190-195.

(7)ZhangYL,YinF,LiuJH*.GeniposideProtectspancreaticINS-1EβcellsfromhIAPP-inducedcelldamage:Potentialinvolvementofinsulindegradingenzyme.CellBiolInt201539(4):373-8.

(8)GuoLX,LiuJH*,YinF,GaoX.Regulationofinsulinsecretionbygeniposide:Possibleinvolvementofphosphatidylinositol3-phosphatekinase.EurRevMedPharmacolSci201418(9):1287-1294.

(9)LiuJH*,GuoLX,YinF,ZhangYL,LiuZX,WangYW.Geniposideregulatesglucose-stimulatedinsulinsecretionpossiblythroughcontrollingglucosemetabolisminINS-1cells.PlosOne20138(10):e78315

(10)LiuJH,ZhangYL,DengXH,YinF*.GeniposidedecreasesthelevelofAβ1-42inthebrainofstreptozotocin-induceddiabeticrats.ActaBiochimBiophySin201345(9):787-91.

(11)YinF,ZhangYL,GuoLX,KongSZ,LiuJH*.Geniposideregulatesinsulin-degradingenzymeexpressiontoinhibitthecytotoxicityofAβ1-42incorticalneurons.CNSNeurologicalDisorders-DrugTargets2012:11(8):1045-51.

(12)LiuJH*,XiaoH,YinF,GuoLX,GaoX.Glucagon-likepeptide1receptorplaysanessentialroleingeniposideattenuatinglipotoxicity-inducedβ-cellapoptosisToxicologyinvitro201226(7):1093-7.

(13)GuoLX,XiaZN,LiuJH*.Glucagon-likepeptide1receptorplaysacriticalroleingeniposide-regulatedinsulinsecretioninINS-1Cells.ActaPharmSin201233:237-41

(14)YinF,LiuJH*,JiXH,WangYW,ZidichouskiJ,ZhangJZ.Silibinin:AnovelinhibitorofAβaggregation.NeurochemInt201158:399-403.

(15)YinF,LiuJH*,JiXH,WangYW,ZidichouskiJ,ZhangJZ.BaicalinpreventstheproductionofhydrogenperoxideandoxidativestressinducedbyAβaggregationinSH-SY5Ycells.NeurosciLett2011492(2):76-9.

(16)YinF,LiuJH*,ZhengXX,GuoLX,XiaoH.GeniposideinducestheexpressionofHO-1viaPI3K/Nrf2-signalingtoenhancetheantioxidantcapacityinprimaryhippocampalneurons.BiolPharmBull201033(11):1841-6.

(17)KongSZ,QianBB,LiuJH,FanMX,ChenG,WangY.Cyclothiazideinducesseizurebehaviorinfreelymovingrats.BrainRes.20101355:207-213.

(18)YinF,LiuJH*,ZhengXX,GuoLX.GLP-1receptorplaysacriticalroleingeniposideregulatingtheexpressionofhemeoxygenase-1inPC12cells.ActaPharmSin201031:540-5.

(19)YinF,LiuJH*,JiX,WangYW,ZidichouskiJ,ZhangJZ.Screeningofinhibitorsforβ-amyloid(Aβ)andhumanisletamyloidpolypeptide(IAPP)aggregationfromAtlanticCanadaplantextracts.PharmaBiol201048(Suppl1):14

(20)YinF,LiuJH*,XiaoH,KongSZ.GeniposidepreventsPC12cellsfromperoxynitriteviaMAPkinasesignalpathway.JHealthSci.201056(2):195-99.

(21)LiuJH*,YinF,GuoLX,DengXH,HuYH.NeuroprotectionofgeniposideagainsthydrogenperoxideinducedPC12cellsinjury:InvolvementofPI3kinasesignalpathway.ActaPharmSin200930(2):159-65.

(22)GuoLX,LiuJH*,XiaZN.GeniposideinhibitsCoCl2-inducedPC12cellsdeathviathemitochondriadependentpathway.ChinMedJ2009122:2886-92.

(23)LiuJH*,YinF,JingJJ,HuYH.Geniposide,anovelagonistforGLP-1receptor,preventsPC12cellsfromoxidativedamageviaMAPkinasepathway.NeurochemInt200751:361-9.

(24)LiuJH*,YinF,ZhengXX,HuYH,GuoLX,DengXH,ChenG,JingJJ,ZhangH.NeurotrophicpropertyofgeniposideforinducingtheneuronaldifferentiationofPC12Cells.IntJDevelopNeurosci200624(7):419-24.

(25)YinF,DengXH,JingJJ.LiuJH*.EffectsoftriethylenetetramineontheG-quadruplexstructureinthehumanc-Mycpromoter.JBiochem2007141:669-74.

(26)GuoLX,YinF,JingJJ,LiuJH*.TriethylenetetraamineinducesthesenescenceofhumanbreastMCF-7cells.Biotechlett200830(1):47-53.

(27)LiuJH*,GuoLX,YinF,ZhengXX,ChenG,WangY.Characterizationandantitumoractivityoftriethylenetetramine,anoveltelomeraseinhibitor.BimedPharmcothera200862:480-5.

(28)KongSZ,LiuJH,RamageAG,andWangY.Cardiacvagalpreganglionicneuronesintheintermediatezoneofthebrainsteminanaesthetizedcats.Expphysi200792(6):1023-8.

(29)JiangB,DuJ,LiuJH,BaoYM,AnLJ.Catalpolattenuatestheneurotoxicityinducedbyβ-amyloid1-42incorticalneuron–gliacultures.BrainRes2008188:139-47.

(30)BiJ,JiangB,LiuJH,LeiC,ZhangXL,AnLJ.ProtectiveeffectsofcatalpolagainstH2O2-inducedoxidativestressinastrocytesprimarycultures.NeurosciLett.2008442(3):224-7.