科研工作:
近年来主持的科研项目:
1) 国家自然科学基金面上项目:SPA-IgG复合体分子内的蛋白质多靶标并行检测(编号:31270988),起止日期:2013.01~2016.12. 2) 国家自然科学基金青年项目:亲和标签肽引导的SPA-IgG组装体导向固定构建三维固相抗体(编号:21105085),起止日期:2012.01~2014.12. 3) 中国博士后科学基金:SPA-IgG超分子复合体构筑三维抗体膜(编号:2014M562118),起止日期:2014.09~2016.12. 4) 湖南省自然科学基金面上项目:差异化修饰葡萄球菌A蛋白构筑自组装三维抗体膜(编号:2015JJ2133),起止日期:2015.01~2017.12. 5) 湖南省教育厅优秀青年项目:亲和标签肽单链融合抗体导向固定探针检测HCV抗原(编号:13B120),起止日期:2013.09~2015.12.
主要代表性论文
1) 3D antibody immobilization on a planar matrix surface. Biosensors and Bioelectronics, 2011, 28: 91-96.2) Effects of heavy metal wastewater on the anoxic/aerobic-membrane bioreactor bioprocess and membrane fouling. Bioresource Technology, 2013, 142: 32-38.3) Facile synthesis of boron and nitride doped MoS2 nanosheets as fluorescence probes for ultrafast, sensitive, and label-free detection of Hg2+. Analyst, 2015, 140: 4654-4661.4) Synthesis of fluorescent BCN hybrid nanosheets: A highly efficient fluorosensor for rapid, simple, sensitive Ag+ detection. RSC Advances, 2015, 5: 52452-52458.5) A new method for multilayered, site-directed immobilization of antibody on polystyrene surface. Biochemical and Biophysical Research Communications, 2014, 450: 429-432.6) Site-oriented immobilization of fusion antigen directed by an affinity ligand, and its validation in an immunoassay. Surface and Interface Analysis, 2011, 43: 1304-1310.7) A novel affinity ligand for polystyrene surface from a phage display random library and its application in anti-HIV-1 ELISA system. Biologicals, 2009, 37: 48-54.8) How an improved immunoassay sensitivity can be achieved by gamma irradiation: modification, application and characterization of polystyrene surface for anti HIV-1 ELISA. Journal of Immunoassay & Immunochemistry, 2009, 30: 457-466.9) Quartz crystal microbalance study of kinetics and thermodynamics of IgG adsorption on the polystyrene surface. Surface Review and Letters, 2015, 22: 1550026, 1-8.10) Research progress on site-oriented and three-dimensional immobilization of protein. Molecular Biology, 2015, 49: 1-20.11) Practical detection for simultaneous analysis of multiple antigens with Staphylococcal protein A as an intermediate. Analytical Methods, 2015, 7: 9018-9025.
发明专利
1) 一种能与聚苯乙烯亲和结合的标签肽及其用于制备酶联免疫固相抗原的方法,专利号:ZL201010274128.9,授权日期:2013年7月31日.2) 一种硼和氮双掺杂的二硫化钼荧光纳米材料的制备方法,专利号:ZL201410753247.0,授权日期:2016年2月17日.