个人简述:

食品、农药和化学品的毒理学安全性评价以及职业病病因学和发病机制的研究，主要包括1,2-二氯乙烷中毒性脑病、1-溴丙烷的神经毒性、三氯乙烯药疹样皮炎、苯中毒血液毒性的中毒机理和生物标志物研究。

科研工作:

(1) Li G, Liang L, Yang J, Zeng L, Xie Z, Zhong Y, Ruan X, Dong M, Yang Z, Lai G, Huang W, Yang A, Chen J, Wu B, Xu H, Meng D, Hu S, Xia L, Yang X, Li L, Ichihara S, Ichihara G, Huang H, Huang Z*. Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: across-sectional study. Nanotoxicology, 2018, 12(6):571-585.(2) Zeng N, Jiang H, Fan Q, Wang T, Rong W, Li G, Li R, Xu D, Guo T, Wang F, Zeng L, Huang M, Zheng J, Lu F, Chen W, Hu Q, Huang Z*, Wang Q*. The aberrant expression of miR-451a contributes to 1,2-DCE induced hepatic glycerol gluconeogenesis disorder by inhibiting glycerol kinase expression in NIH Swiss mice. J Appl Toxicol, 2018, 38(2):292-303.(3) Zhang Y, Li G, Zhong Y, Huang M, Wu J, Zheng J, Rong W, Zeng L, Yin X, Lu F, Xie Z, Xu D, Fan Q, Jia X, Wang T, Hu Q, Chen W, Wang Q*, Huang Z*. 1,2-Dichloroethane induce reproductive toxicity mediated by CREBCREM signaling pathway in male NIH Swiss mouse. Toxicol Sci, 2017, 160(2): 299-314.(4) Wang T, Xu D, Fan Q, Rong W, Zheng J, Gao C, Li G, Zeng N, Guo T, Zeng L, Wang F, Xiao C, Cai L, Tang S, Deng X, Yin X, Huang M, Lu F, Hu Q, Chen W, Huang Z*, Wang Q*.1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice. Toxicology, 2017, 380: 38-49.(5) Huang Z, Ichihara S, Oikawa S, Chang J, Zhang L, Hu S, Huang H, Ichihara G*. Hippocampal phosphoproteomics of F344 rats exposed to 1-bromopropane. Toxicol Appl Pharmacol, 2015, 282(2), 151-160.(6) Huang Z, Ichihara S, Oikawa S, Chang J, Zhang L, Subramanian K, Mohideen SS, and Ichihara G*. Proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure. Toxicol Appl Pharmacol, 2012, 263(1), 44-52.