个人简述:

长期从事感染免疫研究，重点关注脓毒症发生、发展的免疫学及微生态改变，探索脓毒症的发病机理及新的治疗方法。先后获得国家自然基金、广东省医学科学技术研究基金、珠江医院中青年人才库基金、珠江医院院长基金等多项课题。我们的研究显示细胞外组蛋白是导致淋巴细胞凋亡的重要物质，并初步探明了组蛋白介导淋巴细胞凋亡的线粒体通路。

科研工作:

1.Zhanguo Liu, David M. Cauvi, Erika M. A. Bernardino, Bernardo Lara, Radhames E. Lizardo, Dennis Hawisher, Stephen Bickler, Antonio De Maio*. Isolation and characterization of human urine extracellular vesicles. Cell Stress and Chaperones. 2018:23(5):943-953.2.Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y*, Kaplowitz N, Chen P*. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018:69(1):51-59.3. F. Wang, J. Liu, T. Weng, K. Shen, Z. Chen, Y. Yu, Q. Huang, G. Wang, Z. Liu*, S. Jin*.The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short-chain Fatty Acid, Butyrate, through Upregulation of IL-10 in Septic Shock. Scandinavian Journal of Immunology. 2017:85(4):258-263.4. Ping Chang, Bing Mo, David M. Cauvi, Ying Yu, Zhenhui Guo, Jian Zhou, Qiong Huang, Qitao Yan, Guiming Chen, Zhanguo Liu*. Grape seed proanthocyanidin extract protects lymphocytes against histone-induced apoptosis. PeerJ. 2017 5: e3108.5. Ping Chang, Juan Liu, Ying Yu, Shao-Ye Cui, Zhen-Hui Guo, Gui-Ming Chen, Qiong Huang, Zhan-Guo Liu*. Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Inflammatory Mediator Tumor Necrosis Factor-a by Macrophages. Cellular Physiology and Biochemistry, 201742(6):2559-25686. Zhan-Guo Liu, Shu-Yuan Ni, Gui-Ming Chen, Jing Cai, Zhen-Hui Guo, Ping Chang, Yu-Sheng Li.Histones-Mediated Lymphocyte Apoptosis during Sepsis Is Dependent on p38 Phosphorylation and Mitochondrial Permeability Transition.PLoS One. 20138(10): e771317. Liu, Z.，Yuan, X.，Luo, Y.，He, Y.，Jiang, Y.，Chen, Z. K.，Sun, E. Evaluating the effects of immunosuppressants on human immunity using cytokine profiles of whole blood. Cytokine.2009 45(2), 141-147