个人简述:

蔡正旭，男，45岁，医学博士，主任医师，教授，博士研究生导师，现任职于大连医科大学附属第一医院神经内科。1995年毕业于延边大学医学院，2004年于吉林大学第一医院获得神经病学博士学位。2009年带领治疗组以神经系统疾病中癫痫为主要亚专科方向，开展临床及基础研究，建立了丰富的患者数据库。现主持一项国家自然科学基金课题，主持辽宁省科委科技计划项目基金及大连市科委优秀青年基金各一项，参与多项国家及省市课题。获得两项省科技进步三等奖，大连市科技进步二等奖一项，发表学术论文20篇，其中SCI论文9篇，2013年入选大连医科大学首批“英才工程”项目。

科研工作:

研究项目①基于NP-cGMP信号通路探讨肝郁脾虚证FD大鼠脑内及胃内发病机制及逍遥散的干预作用 项目批准号： 81673727国家自然科学基金2017-01-01至 2020 -12-31 主持
②面部情绪对特发性癫痫伴发抑郁症患者脑电活动的影响 项目编号：2012225020辽宁省科委科技计划项目基金 主持
③癫痫患者伴发抑郁症时认知功能变化研究 项目编号：2009J22DW028大连市科委优秀青年基金 主持
④CX36在癫痫发病中的作用及调控机制的实验研究项目编号：QN200614 青年基金 主持
代表文章
1. CaiZhengxu*, Li Song, Li Sheng, Song Fan, Zhang Zhen, Qi Guanhua, Li Tianbai, QiuJuanjuan, Wan Jiajia, Sui Hua, Guo Huishu. Antagonist Targeting microRNA-155 Protects against Lithium-Pilocarpine-Induced Status Epilepticus in C57BL/6 Mice by Activating Brain-Derived Neurotrophic Factor.Front Pharmacol. 2016 May 317:129 IF:4.418
2. Lin Xuelian，Tang Xudong, CaiZhengxu*(共同通讯), Wang Fengyun, Li Ping, Sui Hua, Guo Huishu. (corresponding author)NPs/NPRs Signaling Pathways May Be Involved in Depression-Induced Loss of Gastric ICC by Decreasing the Production of mSCF.PLoS One. 2016 11(2): e0149031. IF:3.057
3.CaiZhengxu, Liang Pin, Xuan Jize, Wan Jiajia, Guo Huishu(corresponding author). ECRG4 as a novel tumor suppressor gene inhibits colorectalcancer cell growth in vitro and in vivo. Tumour Biol. 2016 Jul37(7):9111-204. IF:2.926
4. Zheng Xu Cai , Xu dong Tang, Feng yun Wang, Zhi jun Duan, Yu chun Li, Juan juan Qiu, Hui shu Guo. Effect of gingerol on colonic motility via inhibition of calcium channel current. World J Gastroenterol 2015 21(48): 13466-13472 IF:2.787
5.Zheng-Xu Cai , Hui-Shu Guo , Che Wang , Min Wei, Cheng Cheng , Zhao-Fei Yang, Yin-Wang Chen, Wei-Dong Le, Song Li. Double-edged roles of nitric oxide signaling on APP processing and amyloid-β production in vitro: Preliminary evidence from sodium nitroprusside. Neurotox Res. 2016 Jan29(1):21-34 IF:3.14
6.XINYI GU, ZHENGXU CAI（共同第一）, MING CAI, KUN LIU, DAN LIU, QINSONG ZHANG, JING TAN and QIANG MA. Protective effect of paeoniflorin on inflammation and apoptosis in the cerebral cortex of a transgenic mouse model of Alzheimer's disease. Mol Med Rep. 2016 Mar13(3):2247-52 IF:1.559
7. Wang C, Cai ZX（共同第一）, You ZL, Guo HS, Shang DJ, Wang XL, Zhang L, Ma LJ, Tan J, Le WD, Li S. Free radical scavenging activity and neuroprotective potentials of D138, one Cu(II)/Zn(II) Schiff-base complex derived from N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine. Neurochem Res. 2014 Sep39(9):1834-44. IF:2.472
8.Shu-Ying Zhang, Zheng-Xu Cai（共同第一）, Ping Li, Chun-Yu Cai, Cheng-Long Qu , Hui-Shu Guo Effect of dendroaspis natriuretic peptide (DNP) on L-type calcium channel current and its pathway. Regulatory Peptides2010 164: 120–125. IF:1.813
9.Zhengxu Cai, Yi Li, Qinghui Qi Morphological Changes of Interstitial Cells of Cajal in Deep Muscular Plexus and Enteric Motor Neurons in Intestine of Rats with Multiple Organ Dysfunction Syndrome. Neural Regeneration Research 2010；5（8）：635-640. IF:0.968
10.Zheng Xu Cai，Xu Dong Tang, He Li Gao, Chuangning Tang, Hui Shu Guo. APC, FBXW7, KRAS, PIK3CA, and TP53 gene mutations in human colorectal cancer tumors frequently detected by Next-Generation DNA. Journal of Molecular and Genetic Medicine2014，4(8):1-11