个人简述:

王立辉，男，博士，特聘教授。2006年毕业于沈阳药科大学获药理学博士学位，同年留校任教至今。2004年至2006年曾公派赴韩国首尔国立大学药学院留学深造。2016年至2017年公派赴美国纪念斯隆凯特琳癌症中心（Memorial Sloan KetteringCancer Center）分子药理系访学。目前的主要研究方向为肿瘤表观遗传学、肿瘤耐药和分子靶向治疗。曾先后主持科技部重大新药创制专项（2项）、国家自然科学基金（3项）、中国博士后基金等10余项纵向课题。共发表研究论文和综述60余篇，被SCI收录近50篇，其中以第一作者或通讯作者发表的SCI论文17篇，影响因子高于5的9篇。研究成果曾获得辽宁省自然科学成果奖一等奖2项（排名第一）、二等奖1项（排名第一）、沈阳市自然科学成果奖一等奖1项（排名第一）。

科研工作:

近年来发表的代表性论文:1.WangLH(王立辉),Kim SH,Lee JH,ChoiYL,Kim YC,Park TS,Hong YC,Wu CF,Shin YK.Inactivation of SMAD4tumorsuppressor gene during gastric carcinoma progression. Clin Cancer Res.200713(1):102-10. (SCI，IF=9.6)2.Li M, Yang J, Zhou W, Ren Y, Wang X, Chen H, Zhang J, Chen J, SunY, Cui L, Liu X, Wang LH(王立辉)*, Wu CF*. Activation of an AKT/FOXM1/STMN1 pathway drives resistanceto tyrosine kinase inhibitors in lung cancer.Br J Cancer.2017117(7):974-983. (*通讯作者，SCI，IF=6.2)3.Wang LH(王立辉),Li Y,YangSN,WangFY,Hou Y,Cui W,Chen K,Cao Q,Wang S,Zhang TY,Wang ZZ,Xiao W,Yang JY. WuCF.Gambogic acid synergistically potentiates cisplatin-induced apoptosis innon-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling.Br J Cancer. 2014110(2): 341-52. (SCI，IF=6.2)4.Wang LH(王立辉)*, Dong XY, Ren Y, LuoJJ, Liu P, Su DS, Yang XJ*. Targeting EHMT2 reverses EGFR-TKI resistance inNSCLC by epigenetically regulating the PTEN/AKT signaling pathway，Cell Death Dis. 2018 DOI: 10.1038/s41419-017-0120-6.( *通讯作者，SCI，IF=5.9)5.Wang LH(王立辉), Liu X,Ren Y,ZhangJY,Chen JL,Zhou WL,Guo W,Wang X,Chen H,Li M,Yuan X,Zhang X,Yang JY,WuCF.Cisplatin enriching cancer stem cells confer multidrug-resistance innon-small cell lung cancer via enhancing TRIB1/HDAC activity. Cell Death Dis.20178(4):e2746.(SCI，IF=5.9)6.Wang LH(王立辉),Li HH,Ren Y,Zou S,Fang WH,Jiang XR,Jia LN,Li M,Liu X,Yuan XZ,Chen GL,Yang JY,Wu CF.Targeting HDAC with a novel inhibitor effectively reverses paclitaxelresistance in non-small cell lung cancer via multiple mechanisms. Cell DeathDis. 20167:e2063. (SCI，IF=5.9)7.Wang LH(王立辉),Choi YL,Hua XY,ShinYK,Song YJ,Young SJ,Yun HY,Park SM,Kim WJ,Kim HJ,Choi JS,Kim SH.Increased expression of sonic hedgehog and altered methylation of its promoterregion in gastric cancer and its related lesions. Mod Pathol. 200619(5):675-83(SCI，IF=5.7)8.Wang LH(王立辉), Jiang XR, Chen GL,Guo W, Zhang JY, Cui LJ, Li HH, Li M, Liu X, Yang JY, Wu CF. Anti-tumoractivity of SL4 against breast cancer cells: induction of G2/M arrest throughmodulation of the MAPK-dependent p21 signaling pathway. Sci Rep. 20166:36486. (SCI，IF=5.2)9.Wang LH(王立辉),Chen G,Chen K,RenY,Li H,Jiang X,Jia L,Fu S,Li Y,Liu X,Wang S,Yang J,Wu C.Dual targetingof retinoid X receptor and histone deacetylase with DW22 as a novel antitumorapproach. Oncotarget. 20156(12):9740-55. (SCI，IF=5.0)