个人简述:
邹莉波,女,博士,教授。1983毕业于辽宁中医学院,获医学学士学位;1989年于北京中日友好临床医学研究所获医学硕士学位;1995 年至1999年间,赴日本留学,并于广岛大学医学部取得医学博士学位后归国。2007年3月于沈阳药科大学博士后流动站出站。现任生命科学与生物制药学院药理毒理系主任,校中西医结合学科主席。作为课题负责人主持了国家自然科学基金面上项目2项、教育部博士学科点专项基金等项目多项,参与国家自然科学基金联合项目等多项。目前已在Chem. Sci.等期刊发表论文80余篇,其中,SCI收载论文40余篇。
科研工作:
1.Yang, Y.* Li, G.* Zhao, D. Yu, H. Zheng, X. Peng, X. Zhang, X. Fu, T. Hu, X. Niu, M. Ji, X. Zou, L.* Wang, J.* Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration, Chem. Sci., DOI: 10.1039/C4SC03416C. (IF=9.144)2. Xu, Q.* Ji, X. Chi, T. Liu, P. Jin, G. Gu, S. Zou, L.* Sigma 1 receptor activation regulates brain-derived neurotrophic factor through NR2A-CaMKIV-TORC1 pathway to rescue the impairment of learning and memory induced by brain ischaemia/reperfusion, Psychopharmacology (Berl)., DOI:10.1007/s00213-014-3809-6. (IF=3.54)3. Liu, P.* Zou, L.* Wang, L. Jiao, Q. Chi, T. Ji, X. Jin, G. Xanthoceraside attenuates tau hyperphosphorylation and cognitive deficits in intracerebroventricular-streptozotocin injected rats, Psychopharmacology (Berl)., DOI:10.1007/s00213-013-3240-4. (IF=3.54)4. Ji, X.* Chi, T. Liu, P. Li, L. Xu, J. Xu, Q. Zou, L.* Meng, DL.* The total triterpenoid saponins of Xanthoceras sorbifolia improve learning and memory impairments through against oxidative stress and synaptic damage, Phytomedicine., DOI:10.1016/j.phymed.2016.12.009. (IF=2.937)5. Liu, P.* Zhang, R. Liu, D. Wang, J. Yuan, C. Zhao, X. Li, Y. Ji, X. Chi, T. Zou, L.* Time-course investigation of blood-brain barrier permeability and tight junction protein changes in a rat model of permanent focal ischemia, J. Physiol. Sci., DOI:10.1007/s12576-016-0516-6. (IF=2.165)6. Xu, Q.* Ji, X. Chi, T. Liu, P. Jin, G. Chen, L. Zou, L.* Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor, J Neurol Sci., DOI:10.1016/j.jns.2017.03.027. (IF=2.126)7. Li, Y.* Xu, J.* Xu, P. Song, S. Liu, P. Chi, T. Ji, X. Jin, G. Qiu, S. Hou, Y. Zheng, C. Wang, L. Meng D.* Zou, L.* Xanthoceras sorbifolia extracts ameliorate dendritic spine deficiency and cognitive decline via upregulation of BDNF expression in a rat model of Alzheimer's disease, Neurosci. Lett., DOI:10.1016/j.neulet.2016.07.011. (IF=2.107)8. Jin, G.* Wang, L. Ji, X. Chi, T. Qi, Y. Jiao, Q. Xu, Q. Zhou, X. Zhang, R. Zou, L.* Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice, Neurosci. Lett., DOI:10.1016/j.neulet.2014.04.032. (IF=2.107)9. Zhu, H.* Zou, L.* Tian, J.* Lin, F. He, J. Hou, J. Protective effects of sulphonated formononetin in a rat model of cerebral ischemia and reperfusion injury, Planta. Med., DOI:10.1055/s-0033-1360340. (IF=1.99)10. Ji, X.* Chi, T. Xu, Q. He, X. Zhou, X. Zhang, R. Zou, L.* Xanthoceraside ameliorates mitochondrial dysfunction contributing to theimprovement of learning and memory impairment in mice with intracerebroventricular injection of aβ1-42, Evid. Based. Complement. Alternat. Med., DOI:10.1155/2014/969342. (IF=1.931)主编或参编的教材、专著1.《药理学与毒理学实验》主编, 中国医药科技出版社,20142.《药理学实验》主编, 中国医药科技出版社,20073.《药理学》主编 中国医药科技出版社,2009.14.《药理学学习指导》主编. 国家十一五规划教材配套教材,中国医药科技出版社,20095.《药理学》第四版 副主编 中国医药科技出版社,2015.86.《药理学》第三版 副主编 国家十一五规划教材,中国医药科技出版社,2009年出版7.《药理学》第八版 副主编 国家十二五规划教材,人民卫生出版社,2016.88.《药理学》第七版 副主编 国家十二五规划教材,人民卫生出版社,2011.89.《药理学》全国执业药师应试指南 中国中医药出版社 201110.《中华海洋本草》上海科学技术出版社,2009年出版专利及其他1.中药漏芦中总甾酮的医药用途及制备方法CN1120171C2.一种文冠果总皂苷的制备方法和应用CN103830412B3.一种文冠果壳苷化合物的应用 CN102018718B4.托芬那酸在制备治疗亨廷顿氏症药物中的应用 CN105796540A5.龙血素C在制备防治中枢神经系统疾病药物中的应用 CN106265612A