个人简述:
张浩,男,博士,硕士研究生导师。2008年毕业于中国药科大学,2012年7月毕业于中国医学科学院北京协和医学院。2012年9月至2013年5月在北京协和医学院医药生物技术研究所任助理研究员。2013年6月至2016年7月在美国普渡大学癌症中心从事博士后研究。迄今已在包括Hepatology, Cancer Research, Journal of Hepatology, Oncogene, Oncotarget, Cancer letter, Cancer Science, Cancer Gene Therapy等国内外著名杂志发表论文20余篇,其中第一作者10篇。
科研工作:
代表性论文:1.Hao Zhang, Zheng Xing, Saravana Kumar Kailasam Mani, Brigitte Bancel, David Durantel, Fabien Zoulim, Elizabeth J. Tran, Philippe Merle, Ourania Andrisani. RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.Hepatology, 2016 (IF 11.711)2.Saravana KK Mani, Hao Zhang, Ahmed Diab, Pete E. Pascuzzi, Lydie Lefrançois4, Nadim Fares, Brigitte Bancel, Philippe Merle, Ourania Andrisani. EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes.Journal of Hepatology, 2016(IF: 10.59)3.Hao Zhang, Ahmed Diab, Huitao Fan, Saravana Kumar Kailasam Mani, Ronald Hullinger, Philippe Merle and Ourania Andrisani, Polo-like-kinase1 and long noncoding RNA HOTAIR accelerate proteasomal degradation of SUZ12 and ZNF198 downregulated in Hepatitis B Virus hepatocarcinogenesis,Cancer Research, 2015 (IF 9.284)4.Hao Zhang, Yan Ma, Shenghua Zhang, Hong Liu, Hongwei He, Naren Li, Yuyan Gong, Shuangshuang Zhao, Jian-dong Jiang and Rong-guang Shao, Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway,Oncotarget, 2015 (IF 6.627)5.Hao Zhang, Shenghua Zhanga, Hongwei He, Wuli Zhao, Kaihuan Ren, Jianhua Chen, Rong-guang Shao, RasGAP-derived peptide 38GAP potentiates the cytotoxicity of cisplatin through inhibitions of Akt, ERK and NF-kB in colon carcinoma HCT116 cells,Cancer Letter, 2011(IF 5.016)