个人简述:

1997年--2013年任中国药科大学校长。兼任中国药学会副理事长、中国医药教育协会副会长、江苏省药学会名誉理事长、教育部药学专业学位教学指导委员会副主任委员，中国学位与研究生教育学会药学专业学位工作委员会主任委员，中国高等教育学会药学教育研究会理事长，第五届教育部科学技术委员会学部委员、第十二届江苏省人大代表、全国医药院校药学类教材编委会主任、《中国天然药物》等多家医药杂志、期刊的主编、副主编、编委和特邀编委。吴晓明课题组主要从事抗肿瘤、抗心血管疾病药物、抗糖尿病药物的药物化学研究，在不对称合成反应的基础研究、新型非肽类血管紧张素（Ⅱ）（AⅡ）受体拮抗剂、新型a-葡萄糖苷酶抑制剂等具有生理活性的天然产物的全合成及构效关系等方面进行了大量的研究工作。先后主持和参加国家“863”计划、国家“新药创制”科技重大专项, 国家自然科学基金面上项目等多项国家及省部级科研课题及多项国家重点教改课题，在本学科重要杂志：Chem Commun, Org Lett, Eur J Med Chem, BMC, BMCL, Tetrahedron, Tetrahedron Lett等国内外学术刊物上发表学术论文200余篇，两次获国家级教学成果一等奖，两次获江苏省教学成果特等奖，获江苏省科技进步一等奖、广东省科技进步一等奖，国家留学回国人员成就奖、全国留学回国人员先进个人等，为国务院政府特殊津贴专家。

科研工作:

近期代表性SCI论文：1. Renren Bai, Zhen Wei, Jie Liu, Weijia Xie, Hequan Yao, Xiaoming Wu*, Jieyun Jiang, Qiujuan Wang, Jinyi Xu*. Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists. Bioorganic & Medicinal Chemistry, 2012, 20(15), 4661-4667.2. Dahong Li, Hao Cai, Bowen Jiang, Guyue Liu, Yuetong Wang, Lei Wang, Hequan Yao, Xiaoming Wu*, Yijun Sun, Jinyi Xu*. Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells. European Journal of Medicinal Chemistry, 2013, 59, 322-328.3. Ziyuan Li, Ling Ma, JinyiXu, Lingyi Kong, Xiaoming Wu*, Hequan Yao*. Pd(II)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage. Chemical Communications, 2012, 48(31), 3763-3765.4. Lei Zhao, Ziyuan Li, Lin Chang, JinyiXu, Hequan Yao*, Xiaoming Wu*. Efficient Construction of Fused Indolines with a 2-Quaternary Center via an Intramolecular Heck Reaction with a Low Catalyst Loading. Organic Letters, 2012, 68(14), 2066-2069.5. Renren Bai, Xue Yang, Wen Hong, Yiqun Tang, Shengtao Xu, Hequan Yao, Jieyun Jiang, Jie Liu, Mingqin Shen, Xiaoming Wu*, Jinyi Xu*. Novel hybrids of natural isochroman-4-one bearing N-substituted isopropanolamine as potential antihypertensive candidates. Bioorganic & Medicinal Chemistry, 2013, 21, 2495-2502.6. Dan Liu, Weijia Xie*, Long Liu, Hequan Yao, Jinyi Xu, Genzoh Tanabe, Osamu Muraoka, Xiaoming Wu*. Synthetic study on neoponkoranol and its side chain epimer as potent a-glucosidase inhibitors, optimization of protecting group. Tetrahedron Letters. 2013, 54, 6333-6336.7. Dahong Li, Shengtao Xu, Hao Cai, Lingling Pei, Lei Wang, Hequan Yao, Xiaoming Wu*, Jieyun Jiang, Yijun Sun, Jinyi Xu*. Library construction and biological evaluation of novel enmein-type diterpenoid analogs as potential anticancer agents. Chem. Med. Chem., 2013, 8: 812-818.8. Dahong Li, Shengtao Xu, Hao Cai, Lingling Pei, Hengyuan Zhang, Lei Wang, Hequan Yao, Xiaoming Wu*, Jieyun Jiang, Yijun Sun, Jinyi Xu*. Enmein-type diterpenoid analogs from natural kaurene-type oridonin: synthesis and their antitumor biological evaluation Eur. J. Med. Chem. 2013, 64, 215-221.9. Long Liu, Chengqian Wang, Dan Liu, Weigang He, Jinyi Xu, Aijun Lin, Hequan Yao, Genzoh Tanabe, Osamu Muraoka, Weijia Xie,* Xiaoming Wu,* Construction of 3,6-Anhydrohexosides via Intramolecular Cyclization of Triflates and Its Application to the Synthesis of Natural Product Isolated from Leaves of Sauropus rostratus. Organic Letters 2014, 16, 5004-5007.10. Bo Jiang, Xiaojing Huang, Hequan Yao, Jieyun Jiang, Xiaoming Wu*, Siyi Jiang, Qiujuan Wang, Tao Lu and Jinyi Xu*. Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase. Org. Biomol. Chem., 2014, 12, 2114-2127.