个人简述:

李玉艳，药物化学博士，副教授，中国药科大学药学院药物化学系党支部书记。目前，在阿尔茨海默病和肿瘤的早期诊断探针，干扰肿瘤蛋白-蛋白相互作用等领域展开工作。主持国家自然科学基金1项，江苏省自然科学基金2项，江苏省产学研前瞻性项目1项，企业合作项目1项；参与国家自然科学基金重点项目，国家自然科学基金，国家重大新药创制科技重大专项等多项；在Chemical Science，Green Chem.，Chem.Comm.，European Journal of Medicinal Chemistry等期刊发表论文12篇；授权专利5个。工作在教学科研一线，获得江苏省高校微课教学比赛一等奖&国家优秀奖(2015)，国家科学技术进步二等奖 (第7，2016）。

科研工作:

代表性论文：1, Tuning Stereo-hindrance of Curcumin Scaffold for Selective Imaging of Soluble Forms of Amyloid Beta Species，Yuyan Li, Jian Yang, Hongwu Liu, Jing Yang, Lei Du, Haiwei Feng, Yanli Tian, Jianqin Cao and Chongzhao Ran*，Chemical Science, 2017, 8, 7710 – 7717. （IF8.668）2，Ying Ge, Aibo Li, Jianwei Wu, Haiwei Feng , Letian Wang , Hongwu Liu ,Yungen Xu, Qingxiang Xu ***, Li Zhao **, Yuyan Li *, Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors, European Journal of Medicinal Chemistry, 2017, 128: 180-191. （IF 4.52） 3, Hongwu Liu, Jian Yang, Letian Wang, Yungen Xu, Siyuan Zhang, Jie Lv, Chongzhao Ran, Yuyan Li*, Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes，Future Medicinal Chemistry， 2017 , 9(2), 179-198. （IF 3.58）4, Aibo Li，Haopeng Sun，Lei Du，Xiaoxin Wu，Jianqin Cao，Qidong You，Yuyan Li*，Discovery of novelcovalent proteasome inhibitors through a combination of pharmacophore screening, covalent docking, andmolecular dynamics simulations[J]，Journal of Molecular Modeling，2014，20：2515。（IF 1.98）5, Yanli Tian，Xueli Zhang，Yuyan Li，Timothy M. Shoup，Xin Teng，David R. Elmaleh，Anna Moore*，Chongzhao Ran*，Crown ethers attenuate aggregation of Amyloid beta of Alzheimer’sdisease，Chem.Comm.，2014，50（99）：15792-15795。（IF6.38）6, Ye-Xiang Su, Ya-Hui Deng, Ting-Ting Ma, Yu-Yan Li* and Li-Ping Sun*.“On water”direct Pd-catalysed C–H arylation of thiazolo[5,4-d]pyrimidine derivatives[J]. Green Chem., 2012, 14, 1979（IF 6.32）