科研工作:

国家杰出青年基金——微生物天然产物农药973项目——勃利霉素化学成药性及作用机理研究国家自然科学基金——大豆根内特异微生物及疫霉病菌侵染后根招募微生物代谢活性化合物研究国家自然科学基金——S.avermitilisneau1069生物合成多拉菌素基因簇克隆和关键基因功能分析国家自然科学基金——高选择性谷氨酸门控氯离子通道筛选体系研究与应用教育部“新世纪优秀人才”计划--冰城链霉菌全基因组测序及功能分析黑龙江省首批“长江学者后备人才”启动基金黑龙江省杰出青年基金--冰城链霉菌生物合成米尔贝霉素基因簇及调控基因克隆与高产代谢工程菌的构建。近五年代表性著作、论文： 近5年在BiotechnologyAdvances（IF9.599）、OrganicLetters（IF6.142）等期刊发表SCI论文110余篇，平均影响因子2.0，被美国布朗大学Cane院士等在PNAS、JACS（IF9.9）、NatProdRep（IF9.79）、ChemSocR（IF28.76）、MicrobiolMolBiolR（IF13.02）等他引。发现的新化合物Neaumycin被著名NatProdRep杂志评为2012年“热点研究化合物”；发现的微生物新种Microbisporabryophytorumsp.nov.被国际著名微生物期刊IntJSystEvolMicrobiol作为“封面文章”发表（2015年4月），以及AntonieVanLeeuwenhoek,2014,105(2):307-15论文入选ESIHighlyCitedPapers高被引论文（被引用次数在该学科处于全球前1%水平的科研论文）代表性SCI论文：1、TianJ,ChenH,GuoZ,LiuN,LiJ,HuangY,XiangW(*),ChenY.DiscoveryofpentangularpolyphenolshexaricinsA-CfrommarineStreptosporangiumsp.CGMCC4.7309bygenomemining.ApplMicrobiolBiotechnol.2016doi:10.1007/s00253-015-7248-z2、ZhangB,YangD,YanY,PanG,XiangW(*),ShenB.Overproductionoflactimidomycinbycross-overexpressionofgenesencodingStreptomycesantibioticregulatoryproteins.ApplMicrobiolBiotechnol.2016,100:2267-773、WangH,LiC,ZhangB,HeH,JinP,WangJ,ZhangJ,WangX,XiangW*).CompletegenomesequenceofStreptomycescyaneogriseusssp.noncyanogenus,thethermotolerantproducerofcommercialantibioticsnemadectin.JBiotechnol.2015,204:1-2.4、ZhouD,LiLJ,QiH,PanJJ,ZhangH,WangJD,XiangWS(*).AnewstachybotrincongenerfromasoilfungusStachybotrysparvisporastrainHS-FG-843.JAntibiot(Tokyo).2015,68(5):339-415、LiLJ,ZhouD,ChenAL,HuangJ,ZhangH,WangJD,XiangWS(*).Twonewα-classmilbemycinmetabolitesfrommutantStreptomycesavermitilisNEAU1069-3.JAntibiot(Tokyo).2015,68(5):354-66、LiC,ZhangY,LiuC,WangH,ZhaoJ,LiL,ZhangZ,WangX,XiangW(*).Microbisporabryophytorumsp.nov.,anovelactinomyceteisolatedfrommoss(Bryophyta).IntJSystEvolMicrobiol.201565(4):1274-9封面文章7、GaoR,LiuC,ZhaoJ,JiaF,YuC,YangL,WangX,XiangW(*).Micromonosporajinlongensissp.nov.,isolatedfrommuddysoilinChinaandemendeddescriptionofthegenusMicromonospora,AntonieVanLeeuwenhoek,2014,105(2):307-15(SCI,IF2.137in2014)ESIHighlyCitedPapers（高被引论文），是指论文被引用次数在该学科处于全球前1%水平的科研论文。8、JiangL,SaavedraAN,WayG,AlanisJ,KungR,LiJ,XiangW(*),LiaoJ.SpecificsubstraterecognitionandthioesterintermediatedeterminationsinubiquitinandSUMOconjugationcascadesrevealedbyahigh-sensitiveFRETassay.MolBiosyst.2014,10(4):778-869、JiZhang,JingAn,Ji-JiaWang,Yi-JunYan,Hai-RongHe,Xiang-JingWang,Wen-ShengXiang(*).GeneticengineeringofStreptomycesbingchenggensistoproducemilbemycinsA3/A4asmaincomponentsandeliminatethebiosynthesisofnanchangmycin.ApplMicrobiolBiotechnol.2013(97):1091-8(SCI,IF3.811in2014)10、YangLY,WangJD,ZhangJ,XueCY,ZhangH,WangXJ,XiangWS(*).NewnemadectincongenerswithacaricidalandnematocidalactivityfromStreptomycesmicroflavusneau3Y-3.BioorgMedChemLett.2013(23):5710-311、JiZhang,XiangjingWang,JinnaoDiao,HairongHe,YuejingZhang,WenshengXiang(*).Streptomycinresistance-aidedgenomeshufflingtoimprovedoramectinproductivityofStreptomycesavermitilisNEAU1069.JournalofIndustrialMicrobiologyBiotechnology,2013,63(7):2418-2312、XiangjingWang,FeiyuJia,ChongxiLiu,JunweiZhao,LiangWang,YueShen,JidongWang,JiZhang,ChuangLi,WenshengXiang(*).Xiangellaphaseoligen.nov.,sp.nov.,anewmemberofthefamilyMicromonosporaceae,IntJSystEvolMicrobiol2013,63:2138-4513、LingJiang,YanLiu,YangSong,AmandaN.Saaredra,SongqinPan,WenshengXiang(*),JiayuLiao,InternalCalibrationFӧrsterResonanceEnergyTransferAssay:AReal-TimeApproachforDeterminingProteaseKinetics,Sensors,2013,13,4553-457014、FeiyuJia,ChongxiLiu,XiangjingWang,JunweiZhao,QianfengLiu,JiZhang,RuixiaGao,WenshengXiang(*).Wangellaharbinensisgen.nov.,sp.nov.,anewmemberofthefamilyMicromonosporaceae,AntonievanLeeuwenhoek,2013,103(2):399-40815、Ya-MeiGao,Xiang-JingWang,JiZhang,MingLi,Chong-XiLiu,JingAn,LingJiang,Wen-ShengXiang(*).Borrelidin,apotentantifungalagent:insightintotheantifungalmechanismagainstPhytophthorasojae,JAgricFoodChem,2012,60(39):9874-81,(SCI,IF3.107in2013)16、Sheng-XiongHuang,Xiang-JingWang,YijunYan,Ji-DongWang,JiZhang,Cong-XiLiu,Wen-ShengXiang(*),BenShen.Neaumycin:aNewMacrolidefromStreptomycessp.NEAU-x211,OrganicLetters,2012,14(5):1254-717、PingWang,Guo-junZheng,Ya-pingWang,Xiang-jingWang,He-gengWei,Wen-shengXiang(*).Highlypracticalandcost-efficientsynthesisoftelmisartan:anantihypertensivedrug,Tetrahedron,2012(68):2509-2512(SCI,IF2.817in2014)18、LiuChongxi,ZhangJi,WangXiangjing,QianPingting,WangJidong,GaoYamei,YanYijun,ZhangShuzhen,XuPengfei,LiWenbin,XiangWensheng(*).AntifungalactivityofborrelidinproducedbyaStreptomycesstrainisolatedfromsoybean,JAgricFoodChem2012,60:1251-1257