科研工作:

1.系统鉴定与干细胞多能性维持和ips形成有重要相关性的microRNA或microRNA簇(973)2.猪诱导多能干细胞(iPS)及其分化发育研究(973)3.灵长类细胞多能性的研究（国家重大科学研究计划）4.帕金森病或卢迦雷氏病的治疗性克隆研究与应用(863)5.干细胞多能性标记物发掘及其关键技术研发(863)6.核移植及iPS诱导体细胞重编程机制的研究(基金委重大研究计划)7.DNA与RNA甲基化表观修饰对单倍体胚胎干细胞多能性与所产生个体发育能力的影响和作用机制研究（基金委重大研究计划）8.建立高效重编程体系及多能性细胞检测标准（中国科学院战略性先导科技专项）。近五年代表性著作、论文：1.LiW#,LiX#,LiTD#,JiangMG#,WanHF,LuoGZ,FengCJ,CuiXL,TengF,YuanY,ZhouQ,GuQ,ShuaiL,ShaJH,XiaoYM,WangL,LiuZH,WangXJ,ZhaoXY,ZhouQ*.Geneticmodificationandscreeningintheratusinghaploidembryonicstemcells.CellStemCell.Doi:10.1016/j.stem.2013.11.016.2.LiW#,TengF#,LiT,ZhouQ*.SimultaneousgenerationandgermlinetransmissionofmultiplegenemutationsinratusingCRISPR-Cassystems.NatureBiotechnology31(2013),684–686.3.LiW#,ShuaiL#,WanHF#,DongMZ#,WangM,SangLS,FengCJ,LuoGZ,LiTD,LiX,WangLB,ZhengQY,ShengC,WuHJ,LiuZH,LiuL,WangL,WangXJ,ZhaoXY*,ZhouQ*.Androgenetichaploidembryonicstemcellsproducelivetransgenicmice.Nature.490(7420)(2012):407-11.4.ShengC#,ZhengQY#,WuJY#,XuZ,SangLS,WangLB,GuoCL,ZhuWW,TongM,LiuL,LiW,LiuZH,ZhaoXY,WangL,ChenZG*,ZhouQ*.Generationofdopaminergicneuronsdirectlyfrommousefibroblastsandfibroblast-derivedneuralprogenitors.CellRes.22(4)(2012):769-772.5.GuQ#,HaoJ#,ZhaoXY,LiW,LiuL,WangL,LiuZH,ZhouQ*.RapidconversionofhumanESCsintomouseESC-likepluripotentstatebyoptimizingcultureconditions.Protein&Cell.(2012)3(1):71-796.ShengC#,ZhengQY#,WuJY#,XuZ,WangLB,LiW,ZhangHJ,ZhaoXY,LiuL,WangZW,GuoCL,WuHJ,LiuZH,WangL,HeSG,WangXJ,ChenZG*,ZhouQ*.Directreprogrammingofsetolicellsintomultipotentneuralstemcellsbydefinedfactors.CellRes.22(1)(2012):208-218.7.LiW#,ZhaoXY#,WanHF,ZhangY,LiuL,LvZ,WangXJ,WangL*,ZhouQ*.iPScellsgeneratedwithoutc-MychaveactiveDlk1-Dio3regionandarecapableofproducingfull-termmicethroughtetraploidcomplementation.CellRes.21(3)(2011):550-3.8.LiuL#,LuoGZ#,YangW#,ZhaoX#,ZhengQ,LvZ,LiW,WuHJ,WangL,WangXJ*,ZhouQ*.ActivationoftheimprintedDlk1-Dio3regioncorrelateswithpluripotencylevelsofmousestemcells.JBiolChem.285(2010):19483-19490.9.ZhaoXY#,LiW#,LvZ#,LiuL,TongM,HaiT,HaoJ,GuoCL,MaQW,WangL,ZengFY*,ZhouQ*.iPScellsproduceviablemicethroughtetraploidcomplementation.Nature.461(7260)(2009):86-90.10.YuY#,WuJD#,FanY,LvZ,GuoXJ,ZhaoC,ZhouR,ZhangZ,WangFQ,XiaoM,ChenL,ZhuH,ChenW,LinM,LiuJY,ZhouZM,WangL,HuoH*,ZhouQ*,ShaJH.Evaluationofblastomerebiopsyusingmousemodelindicatesthepotentialhigh-riskofneurodegenerativedisordersintheoffspring.MolCellProteomics.8(7)(2009):1490-1500.11.YuY#,DingCH#,WangEY,ChenXJ,LiXM,ZhaoCL,FanY,WangL,BeaujeanN,ZhouQ,JouneauA*,JiWZ*.Piezo-assistednucleartransferaffectscloningefficiencyandmaycauseapoptosis.Reproduction.133(5)(2007):947-954.