个人简述:

博士，副教授，浙江理工大学生命科学学院生物化学与分子生物学、细胞生物学专业硕士生导师。浙江理工大学生命科学学院党委委员、细胞生物学学科组主任，浙江理工大学新元医学与生物技术研究所所长助理，主讲《分子生物学》、《生命科学导论》和《生物伦理探密》等本科生课程，《现代生物学综合大实验》研究生课程。

科研工作:

科研项目

1. 国家自然科学基金：掌叶半夏凝集素ppa细胞内杀伤肺癌的机制 2009.1-2011.12；主持

2. 国家自然科学基金：通过急性髓性白血病干细胞表面CD123导入溶瘤腺病毒的实验研究 2009.1-2011.12；参与，排名3/6

3. 浙江省自然科学基金：靶向survivin的溶瘤腺病毒的构建及其在恶性肿瘤中的治疗研究 2010.1-2011.12；主持

4. 浙江省“生物医学工程”重中之重学科开放基金：溶瘤腺病毒载体携带新型抑癌基因TSLC1治疗肿瘤的研究 2009.1-2009.12；主持

5. 浙江理工大学科研启动基金：双靶向溶瘤腺病毒载体的构建及其在恶性肿瘤中的治疗研究 2011.1-2013.12；主持

6. 浙江省自然科学基金重点项目（项目批准号：LZ13H160004）：靶向双基因-病毒载体的策略设计及其抗恶性肿瘤的效果研究 2013.1-2016.12；主持

7. 国家自然科学基金资助项目（项目编号：81272687）：基于Wnt/β-catenin信号通路探讨TSLC1在肝癌中的作用及其分子机制 2013.1-2016.12；主持

共发表学术论文50多篇，其中SCI收录论文20多篇，申请国家发明专利3项。

代表性论文

LF He*, YG Wang*, T Xiao, KJ Zhang, GC Li, JF Gu, L Chu, WH Tang, WS Tan, XY Liu. Suppression of cancer growth in mice by adeno-associated virus vector-mediated IFN-β expression driven by hTERT promoter. Cancer Letters. 2009, 286(2): 196-205. (* as first co-author)

Liu X, Wang Y, Niu H, Zhang X, Tan WS. The improvement of adenovirus vector production by increased expression of coxsackie adenovirus receptor. Biotechnol Lett. 2009, 31(7): 939-44.

Xuping Liu, Liang Zhao, Yigang Wang, Xu Zhang and Wen-Song Tan. Effects of calcium ion on adenovirus production with high densities of HEK293 cells. J Biotechnol. 2010, 15(3): 414-420.

Yigang Wang, Kangjian Zhang, Haibo Cai, Yumei Wu, Guoqing He, Wen-Song Tan. The efficacy of combination therapy using Adeno-associated virus-TRAIL targeting to telomerase activity and cisplatin in a mice model of hepatocellular Carcinoma. J Cancer Res Clin Oncol, 2010, 136(12): 1827-1837.

谢宏霞, 曾凤辉, 刘鸿, 蒋海, 王毅刚*. 磷酸化和乙酰化修饰对STAT3功能的调节. 中国细胞生物学学报. 2010, 32(1): 115-120.

Xiao L, Li X, Niu N, Qian J, Xie G, Wang Y*. Dichloroacetate (DCA) enhances tumor cell death in combination with oncolytic adenovirus armed with MDA-7/IL-24. Mol Cell Biochem. 2010, 340(1-2): 31-40.

Yigang Wang, Lingfeng He, Guoqing He, Yanping Kong, Xuping Liu, Haibo Cai, Xinyuan Liu and Wensong Tan. Enhanced antitumor effect of combining interferonβ with TRAIL mediated by tumor-targeting adeno-associated virus vector on A549 lung cancer xenograft. 生物工程学报(英文版). Chin J Biotech 2010, 26(6): 780–788.

Zhong S, Yu D, Wang Y, Qiu S, Wu S, Liu XY. An armed oncolytic adenovirus ZD55-IL-24 combined with ADM or DDP demonstrated enhanced antitumor effect in lung cancer. Acta Oncol. 2010, 49(1): 91-9.

van der Laan LJ*, Wang Y*, Tilanus HW, Janssen HL, Pan Q. AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application? Expert Opin Biol Ther. 2011, 11(3):315-27. (* as first co-author)

He G, Lei W, Wang S, Xiao R, Guo K, Xia Y, Zhou X, Zhang K, Liu X, WangY*. Overexpression of tumor suppressor TSLC1 by a survivin-regulated oncolytic adenovirus significantly inhibits hepatocellular carcinoma growth. J Cancer Res Clin Oncol. 2012 Apr138(4):657-70

Zhou XM, Xie GL, Wang SB, Wang YG, Zhang KJ, et al. Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene. Plos one, 2012, 20127(10):e47566.

Shi-bing Wang, Yuan Tan, Wen Lei, Yi-gang Wang, Xiu-mei Zhou, Kang-jian Zhang, Liang Chu, Xin-yuan Liu, Wen-bin Qian (2012) Complete eradication of xenograft hepatoma by oncolytic adenovirus ZD55 harboring TRAIL-IETD-Smac gene with broad antitumor effect. Human Gene Therapy, 23(9): 992-1002.

Lei W, Liu HB, Wang SB, Zhou XM, Zheng SD, Guo KN, Ma BY, Xia YL, Tan WS, Liu XY, Wang YG*. Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model. Acta Pharmacol Sin. 2013 Apr34(4):531-40.

培养研究生已毕业8人，在读4人，发表多篇SCI收录论文；

指导本科生多人，多次获得优秀毕业论文，研究生和本科生主持创新创业计划及浙江省新苗人才计划项目多项。

浙江省第十一届挑战杯“动感地带”大学生课外学术科技作品竞赛 二等奖

VISA载体携带IL-24和TRAIL双基因抑制肝癌细胞生长的效应 指导老师

指导本科生以第1作者发表中文核心学术论文3篇。