个人简述:

　　牧启田，主任技师，九三学社社员，干细胞移植实验室副主任，宁波市领军拔尖人才培养工程第二层次培养对象，宁波市医学会血液分会委员，宁波市宁波大学硕士生导师，tumor biology 杂志审稿人。1996年获皖南医学院临床医学学士学位，2003年获暨南大学血液内科学硕士学位，2013.3获得浙江大学博士学位。2003年至今一直在宁波市第一医院宁波市干细胞移植重点实验室工作，从事白血病分子细胞遗传学研究。发表论文60余篇, 其中sci论文10余篇，2011年美国ASH Meeting 论文摘要交流1篇，2012年美国ASH Meeting 论以poster形式论文交流1篇，多次全国学术会议做论文口头报告。目前，主持浙江省自然科学基金项目1项，市级科技项目1项；参与获得市厅级科技创新进步奖5项，获得2007-2008年度宁波市自然科学论文优秀奖1项。

科研工作:

　代表性的文章：

1. Chen J, Mu Q, Li X, Yin X, Yu M, Jin J, Li C, Zhou Y, Zhou J, Suo S, Lu D, Jin J. Homoharringtonine targets Smad3 and TGF-β pathway to inhibit the proliferation of acute myeloid leukemia cells. Oncotarget, 2017 Jun 208(25):40318-40326.（并列第一作者）.

2. Mu Q, Guo L, Hu Y, Sheng L, Zhang Y, Wu N, Chen Y, Shi C, Shi S, Wu Y, Ouyang G. SNX2-ABL1-positive acute lymphoblastic leukemia possibly has a poor prognosis. Leuk Lymphoma. 2017, Sep58(9):1-3.

3. Qitian Mu，Ying Chen，Huiling Zhu，Yi Zhang，Ningning Wu，Yanru Lou，Songqiu Shi，Ying Wu，Cong Shi，Guifang Ouyang. Isolated trisomy 13 inrefractory anemia with excess blasts: report of two cases and a brief literature review of this possible association，LeukLymphoma, 2016, 57(2):493-495.

4. Shasha Lu, Qitian Mu，Mengxia Yu，Xiufeng Yin，Jian Chen，Jie Jin.Overexpression of musashi2 is possibly associated with chemoresistance in T-cell acute lymphoblastic leukemia，Leuk Lymphoma, 2016, 57(2):467-469。

5. Ma QL, Wang JH, Wang YG, Hu C, Mu QT, Yu MX, Wang L, Wang DM, Yang M, Yin XF, Chen FF, Lu SS, et al. High IDH1 expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia. Int J Cancer 2015137:1058-1065。

6. Mu Q, Ma Q, Lu S, Zhang T, Yu M, Huang X, Chen J, Jin J. 10058-F4, a c-Myc inhibitor, markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells. Oncol Lett 20148: 1355-9.

7. Yin XF, Ma QL, Mu QT, Shao L, Wang SS, Meng HT, Xu WL, Wang YG, Chen ZM, Chen FF, Jin J. Outcome prediction by the transcript level of BCR-ABL at 3 months in patients with chronic myeloid leukemia treated with imatinib--a single institution historical experience. Leuk Res 201438: 1191-8.

8. Lu S, Xu Y, Mu Q, Cao L, Chen J, Zhu Z, Lou Y, Meng H, Qian W, Tong H, Mai W, Huang J, et al. The risk of hepatitis B virus reactivation and the role of antiviral prophylaxis in hepatitis B surface antigen negative/hepatitis B core antibody positive patients with diffuse large B-cell lymphoma receiving rituximab-based chemotherapy. Leuk Lymphoma 2014: 1-6.

9. Mu Q, Wang Y, Chen B, Qian W, Meng H, Tong H, Chen F, Ma Q, Ni W, Chen S, Jin J. High expression of Musashi-2 indicates poor prognosis in adult B-cell acute lymphoblastic leukemia. Leuk Res 201337: 922-7.

10. Mu Q, Ma Q, Wang Y, Chen Z, Tong X, Chen FF, Lu Y, Jin J. Cytogenetic profile of 1,863 Ph/BCR-ABL-positive chronic myelogenous leukemia patients from the Chinese population. Ann Hematol 201291: 1065-72.

11. Yang L, Ruan LM, Ye HH, Cui HB, Mu QT, Lou YR, Ji YX, Li WZ, Sun DH, Chen XB. Depression is associated with lower circulating endothelial progenitor cells and increased inflammatory markers. Acta Neuropsychiatr 201123: 235-40.

12. Mu Q, Cheng Y, Xu W, Wang Y, Chen Z, Jin J. Acquired Robertsonian translocation is not always suggestive of poor prognosis: a case of acquired Rob(1314) in Philadelphia chromosome-negative cells of chronic myelogenous leukemia. Leuk Lymphoma 201051: 2141-3.

13. Zhuo Z, Zhang L, Mu Q, Lou Y, Gong Z, Shi Y, Ouyang G, Zhang Y. The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells. In Vitro Cell Dev Biol Anim 200945: 69-74.

1.《Bcl2l12基因在白血病中表达及其临床意义》，宁波市医学科技计划项目基金。

2.《Musashi-2基因在急性淋巴细胞白血病中表达的临床意义研究》，宁波市医学科技计划项目基金。

3.《Musashi-2基因在B细胞急性淋巴细胞白血病中分子作用机制研究》, 宁波市自然科学基金项目。

4.《MSI2通过p53-WNT通路促进成人B细胞急性淋巴细胞白血病生长作用的机制研究》，浙江省自然科学基金项目。