科研工作:

1、现代农业产业技术体系，蛋鸡产业疫病控制，350万元；2、国家科技支撑计划课题，禽流感等重要家禽疫病流行毒疫苗研究与开发，86.25万元；3、基础支撑科研专项，禽呼吸道病创新团队，591.45万元；4、公益性行业（农业）科研专项，鸡新城疫防控技术研究与示范，108万元；5、哈尔滨市科技攻关计划项目，新城疫和传染性支气管炎二联疫苗，70万元。近五年代表性著作、论文：（1）ZongxiHan,TingtingZhang,QianqianXu,MengyingGao,YuqiuChen,QiulingWang,YanZhao,YuhaoShao,HuixinLi,XiangangKong,ShengwangLiu*,Alteredpathogenicityofatl/CH/LDT3/03genotypeinfectiousbronchitiscoronavirusduetonaturalrecombinationinthe5′-17kbregionofthegenome.VirusResearch，VirusResearch,2016,213:140-148(2)HaiLi,FengjieWang,ZongxiHan,QiGao,HuixinLi,YuhaoShao,NanaSunandShengwangLiu.Genome-widegeneexpressionanalysisidentifiestheproto-oncogenetyrosine-proteinkinaseSrcasacrucialvirulencedeterminantoftheinfectiouslaryngotracheitisvirusinchickencells.JournalofVirology,2016,90(1):9-21(3)LingfengChen,TingtingZhang,ZongxiHan,XiangangKong,ShengwangLiu.MolecularandantigeniccharacteristicsofMassachusettsgenotypeinfectiousbronchitiscoronavirusinChina.VeterinaryMicrobiology,2015,181(3-4):241-251(4)QianqianXu,ZongxiHan,QiulingWang,TingtingZhang,MengyingGao,YanZhao,YuhaoShao,HuixinLi,XiangangKong,ShengwangLiu*,EmergenceofNovelNephropathogenicInfectiousBronchitisVirusesCurrentlyCirculatinginChineseChickenFlocks,AvianPathology.2015,9:1-37(5)YanyanLi,QianqianXu,TingtingZhang,MengyingGao,QiulingWang,ZongxiHan,YuhaoShao,DeyingMaandShengwangLiu,HostAvianBeta-DefensinandToll-LikeReceptorResponsesofPigeonsfollowingInfectionwithPigeonParamyxovirusType1,AppliedandEnvironmentalMicrobiology,2015,81(18):6415-6424(6)YangXu,TingtingZhang,QianqianXu,ZongxiHan,ShulingLiang,YuhaoShao,DeyingMa,ShengwangLiu*,Differentialmodulationofavianβ-defensinandToll-likereceptorexpressioninchickensinfectedwithinfectiousbronchitisvirus,AppliedandMicrobiologyBiotechnology2015,99(21):9011-9024(7)TingtingZhang,ZongxiHan,QianqianXu,QiulingWang,MengyingGao,WeiWu,YuhaoShao,HuixinLi,XiangangKong,ShengwangLiu*,Serotypeshiftofa793/Bgenotypeinfectiousbronchitiscoronavirusbynaturalrecombination,Infection,GeneticsandEvolution,2015,32:377-387(8)WeiWu,HuairanLiu,TingtingZhang,ZongxiHan,YanyuJiang,QianqianXu,YuhaoShao,HuixinLi,XiangangKong,HongyanChen*,ShengwangLiu*,MolecularandantigeniccharacteristicsofNewcastlediseasevirusisolatesfromdomesticducksinChina,Infection,GeneticsandEvolution,2015,32:34-43(9)FeiZhao,ZongxiHan,TingtingZhang,YushaoHao,XiangangKong,HuijieMa,ShengwangLiu*,GenomiccharacteristicsandchangesofavianinfectiousbronchitisvirusstrainCK/CH/LDL/97Iafterserialpassagesinchickenembryos,Intervirology,2014,57(6):319-330(10)ShengwangLiu*,QianqianXu,ZongxiHan,XiaoliLiu,HuixinLi,HongboGuo,NanaSun,YuhaoShao,XiangangKong,Originandcharacteristicsoftherecombinantnovelavianinfectiousbronchitiscoronavirusisolateck/CH/LJL/111054,Infection,GeneticsandEvolution,2014,23:189-195(11)JunfengSun,ZongxiHan,YuhaoShao,ZhongzanCao,XiangangKong,ShengwangLiu*,Comparativeproteomeanalysisoftrachealtissuesinresponsetoinfectiousbronchitiscoronavirus,Newcastlediseasevirus,andavianinfluenzavirusH9subtypevirusinfection,Proteomics,2014,14(11):1403-1423(12)HongboGuo,XiaoliLiu,YangXu,ZongxiHan,YuhaoShao,XiangangKong,ShengwangLiu*,AcomparativestudyofpigeonsandchickensexperimentallyinfectedwithPPMV-1todetermineantigenicrelationshipsbetweenPPMV-1andNDVstrains,VeterinaryMicrobiology,2014,168(1):88-97(13)FengCong,XiaoliLiu,ZongxiHan,YuhaoShao,XiangangKong,ShengwangLiu*,Transcriptomeanalysisofchickenkidneytissuesfollowingcoronavirusavianinfectiousbronchitisvirusinfection,BMCGenomics,2013,14:743(14)HongboGuo,XiaoliLiu,ZongxiHan,YuhaoShao,JindingChen,ShashaZhao,XiangangKong,ShengwangLiu*,Phylogeneticanalysisandcomparisonofeightstrainsofpigeonparamyxovirustype1(PPMV-1)isolatedinChinabetween2010and2012,ArchievesofVirology,2013,158(6):1121-1131(15)XiaoliLiu,HuijieMa,QianqianXu,NanaSun,ZongxiHan,ChuyangSun,HongboGuo,YuhaoShao,XiangangKong,ShengwangLiu*,CharacterizationofarecombinantcoronavirusinfectiousbronchitisviruswithdistinctS1subunitsofspikeandnucleocapsidgenesanda3′-untranslatedregion,VeterinaryMicrobiology.2013,162(2-4):429-436(16)XiaoliLiu,YuhaoShao,HuijieMa,ChuyangSun,XiaonanZhang,ChengrenLi,ZongxiHan,BaolongYan,XiangangKong,ShengwangLiu*,ComparativeanalysisoffourMassachusettstypeinfectiousbronchitiscoronavirusgenomesrevealsanovelMassachusettstypestrainandevidenceofnaturalrecombinationinthegenome,Infection,GeneticsandEvolution,2013,14:29-38(17)DeyingMa*,MingyueZhang,KexinZhang,XiaoliLiu,ZongxiHan,YuhaoShao,ShengwangLiu*,Identificationofthreenovelavianbeta-defensinsfromgooseandtheirsignificanceinthepathogenesisofSalmonella.MolecularImmunology,2013,56(4):521-529（18）ZongxiHan,FeiZhao,YuhaoShao,XiaoliLiu,XiangangKong,YangSong,ShengwangLiu*,FinelevelepitopemappingandconservationanalysisoftwonovellinearB-cellepitopesoftheavianinfectiousbronchitiscoronavirusnucleocapsidprotein.VirusResearch，2013,171(1):54-64(19)DeyingMa*,KexinZhang,MingyueZhang,ShengnanXin,XiaoliLiu,ZongxiHan,YuhaoShao,ShengwangLiu*.Identification,ExpressionandActivityAnalysesofFiveNovelDuckBeta-Defensins,PLoSOne.2012,7(10):e47743(20)HuijieMa,YuhaoShao,ChuyangSun,ZongxiHan,XiaoliLiu,HongboGuo,XiaozhenLiu,XiangangKong,ShengwangLiu*,GeneticdiversityofavianinfectiousbronchitiscoronavirusinrecentyearsinChina,AvianDiseases,2012,56(1):15-28(21)ZhongzanCao,ZongxiHan,YuhaoShao,XiaoliLiu,JunfengSun,DanYu,XiangangKong,ShengwangLiu*.Proteomicsanalysisofdifferentiallyexpressedproteinsinchickentracheaandkidneyafterinfectionwiththehighlyvirulentandattenuatedcoronavirusinfectiousbronchitisvirusinvivo.ProteomeScience,2012,10:24(22)ZhongzanCao,ZongxiHan,YuhaoShao,HeyuanGeng,XiangangKong,ShengwangLiu*.Proteomicanalysisofchickenembryonictracheaandkidneytissuesafterinfectioninovobyavianinfectiousbronchitiscoronavirus.ProteomeScience,2011,9:11(23)ChuyangSun,ZongxiHan,HuijieMa,QingxiaZhang,BaolongYan,YuhaoShao,JiaXu,XiangangKong,ShengwangLiu*,PhylogeneticanalysisofinfectiousbronchitiscoronavirusesnewlyisolatedinChina,andpathogenicityandevaluationofprotectioninducedbyMassachusettsserotypeH120vaccineagainstQX-likestrains,AvianPathology,2011,40(1):43-54(24)DeyingMa,CaiyuanZhou,MingyueZhang,ZongxiHan,YuhaoShao,ShengwangLiu*,Functionalanalysisandinductionoffournovelgoose(Ansercygnoides)avianβ-defensinsinresponsetosalmonellaenteritidisinfection,ComparativeImmunology,MicrobiologyandInfectiousDiseases,2012，35(2):197-207(25)DeyingMa,LijuanLin,KexinZhang,ZongxiHan,YuhaoShao,RuiqinWang,ShengwangLiu*,DiscoveryandcharacterizationofCoturnixchinensisavianβ-defensin10,withbroadantibacterialactivity,JournalofPeptideScience,201218(4):224-232(26)XiaoliLiu,ZongxiHan,YuhaoShao,YangLi,HuixinLi,XiangangKong,ShengwangLiu.DifferentlinkagesinthelongandshortregionsofthegenomesofduckenteritisvirusClone-03andVACstrains,VirologyJournal,2011,8:200(27)DeyingMa,LijuanLin,KeixnZhang,ZongxiHan,YuhaoShao,XiaoliLiu,ShengwangLiu*，ThreenovelAnasplatyrhynchosavianβ-defensins,upregulatedbyduckhepatitisvirus,withantibacterialandantiviralactivities,MolecularImmunology,2011,49(1-2):84-96（18）ZongxiHan,ChuyangSun,BaolongYan,XiaonanZhang,YuWang,ChengrenLi,QingxiaZhang,YazhenMa,YuhaoShao,QiaoranLiu,XiangangKong,ShengwangLiu*,A15-yearanalysisofmolecularepidemiologyofavianinfectiousbronchitiscoronavirusinChina,Infection,GeneticsandEvolution,2011,11(1):190-200专著：兽医免疫学，中国农业出版社，2012-09-01出版兽医微生物，中国农业出版社，2013-12-30出版现代动物病毒学，中国农业出版社，2014-12-24出版