个人简述:

肖丙秀，女，学士，副高职称。曾在美国明尼苏达大学Hormel研究所癌生物学实验室进修学习。目前从事肿瘤学、分子生物学教学与研究工作。曾参与完成国家自然科学基金课题3项。主持完成浙江省自然科学基金项目和浙江省科技厅科研项目各1 项，在肿瘤相关非编码rna研究方面具有较丰富的经验，形成了胃癌诊治研究特色。近年来发表论文30多篇，其中SCI收录20多篇。获得省科技奖三等奖2项、市厅级科技奖一等奖2项、市厅级科技奖二等奖2项、市厅级科技奖三等奖2项和市厅级科技奖三等奖2项等，其中“外周血中微量消化系统恶性肿瘤细胞的分析及其临床应用”已在4家医院（包括2家三甲医院）推广应用，取得了良好的社会效益，成果获得2006年浙江省科学技术奖三等奖和浙江省医药卫生科技创新奖一等奖。申报发表专利6项，其中2项已授权。

科研工作:

1: Shao Y, Li J, Lu R, Li T, Yang Y, Xiao B, Guo J. Global circular RNAexpression profile of human gastric cancer and its clinical significance. Cancer Med. 2017 Jun6(6):1173-1180. doi: 10.1002/cam4.1055. Epub 2017 May 23. PubMedPMID: 28544609 PubMed Central PMCID: PMC5463069.2: Fu L, Wu S, Yao T, Chen Q, Xie Y, Ying S, Chen Z, Xiao B, Hu Y. Decreasedexpression of hsa_circ_0003570 in hepatocellular carcinoma and its clinicalsignificance. J Clin Lab Anal. 2017 May 11. doi: 10.1002/jcla.22239. [Epub ahead of print] PubMed PMID: 28493512.3: Chen S, Li T, Zhao Q, Xiao B, Guo J. Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta. 2017Mar466:167-171. doi: 10.1016/j.cca.2017.01.025. Epub 2017 Jan 24. PubMed PMID:28130019.4: Li P, Chen H, Chen S, Mo X, Li T, Xiao B, Yu R, Guo J. Circular RNA 0000096affects cell growth and migration in gastric cancer. Br J Cancer. 2017 Feb28116(5):626-633. doi: 10.1038/bjc.2016.451. Epub 2017 Jan 12. PubMed PMID:28081541 PubMed Central PMCID: PMC5344286.5: Liu GY, Xiao BP, Luo CF, Zhuang YQ, Xu RM, Ma WH. Results of a modifiedposterolateral approach for the isolated posterolateral tibial plateau fracture. Indian J Orthop. 2016 Mar-Apr50(2):117-22. doi: 10.4103/0019-5413.177578. PubMedPMID: 27053799 PubMed Central PMCID: PMC4800952.6: Li P, Chen S, Chen H, Mo X, Li T, Shao Y, Xiao B, Guo J. Using circular RNA asa novel type of biomarker in the screening of gastric cancer. Clin Chim Acta.2015 Apr 15444:132-6. doi: 10.1016/j.cca.2015.02.018. Epub 2015 Feb 14. PubMedPMID: 25689795.7: Xia T, Liao Q, Jiang X, Shao Y, Xiao B, Xi Y, Guo J. Long noncoding RNAassociated-competing endogenous RNAs in gastric cancer. Sci Rep. 2014 Aug154:6088. doi: 10.1038/srep06088. PubMed PMID: 25124853 PubMed Central PMCID:PMC4133709.8: Shao Y, Ye M, Jiang X, Sun W, Ding X, Liu Z, Ye G, Zhang X, Xiao B, Guo J.Gastric juice long noncoding RNA used as a tumor marker for screening gastriccancer. Cancer. 2014 Nov 1120(21):3320-8. doi: 10.1002/cncr.28882. Epub 2014 Jul1. PubMed PMID: 24986041.9: Yu X, Wu Y, Liu Y, Deng H, Shen Z, Xiao B, Guo J. miR-21, miR-106b and miR-375as novel potential biomarkers for laryngeal squamous cell carcinoma. Curr PharmBiotechnol. 201415(5):503-8. PubMed PMID: 24846066.10: Li PF, Chen SC, Xia T, Jiang XM, Shao YF, Xiao BX, Guo JM. Non-coding RNAsand gastric cancer. World J Gastroenterol. 2014 May 1420(18):5411-9. doi:10.3748/wjg.v20.i18.5411. Review. PubMed PMID: 24833871 PubMed Central PMCID:PMC4017056.11: Yu X, Song H, Xia T, Han S, Xiao B, Luo L, Xi Y, Guo J. Growth inhibitoryeffects of three miR-129 family members on gastric cancer. Gene. 2013 Dec10532(1):87-93. doi: 10.1016/j.gene.2013.09.048. Epub 2013 Sep 20. PubMed PMID: 24055727.12: Xiao B, Guo J. Long noncoding RNA AC096655.1-002 has been officially named asgastric cancer-associated transcript 1, GACAT1. Tumour Biol. 2013 Oct34(5):3271.doi: 10.1007/s13277-013-0916-7. Epub 2013 Jun 12. PubMed PMID: 23754450.13: Cui L, Zhang X, Ye G, Zheng T, Song H, Deng H, Xiao B, Xia T, Yu X, Le Y, GuoJ. Gastric juice MicroRNAs as potential biomarkers for the screening of gastriccancer. Cancer. 2013 May 1119(9):1618-26. doi: 10.1002/cncr.27903. Epub 2013 Jan18. PubMed PMID: 23335180.14: Deng H, Guo Y, Song H, Xiao B, Sun W, Liu Z, Yu X, Xia T, Cui L, Guo J.MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigeneticalregulation in gastric cancer. Gene. 2013 Apr 15518(2):351-9. doi:10.1016/j.gene.2012.12.103. Epub 2013 Jan 17. PubMed PMID: 23333942.15: Zhou H, Xiao B, Zhou F, Deng H, Zhang X, Lou Y, Gong Z, Du C, Guo J. MiR-421 is a functional marker of circulating tumor cells in gastric cancer patients.Biomarkers. 2012 Mar17(2):104-10. doi: 10.3109/1354750X.2011.614961. Epub 2012Jan 23. PubMed PMID: 22263628.16: Li LZ, Deng HX, Lou WZ, Sun XY, Song MW, Tao J, Xiao BX, Guo JM. Growthinhibitory effect of 4-phenyl butyric acid on human gastric cancer cells isassociated with cell cycle arrest. World J Gastroenterol. 2012 Jan 718(1):79-83.doi: 10.3748/wjg.v18.i1.79. PubMed PMID: 22228974 PubMed Central PMCID:PMC3251809.17: Cheng J, Deng H, Xiao B, Zhou H, Zhou F, Shen Z, Guo J. piR-823, a novelnon-coding small RNA, demonstrates in vitro and in vivo tumor suppressiveactivity in human gastric cancer cells. Cancer Lett. 2012 Feb 1315(1):12-7. doi:10.1016/j.canlet.2011.10.004. Epub 2011 Oct 10. PubMed PMID: 22047710.18: Cui L, Lou Y, Zhang X, Zhou H, Deng H, Song H, Yu X, Xiao B, Wang W, Guo J.Detection of circulating tumor cells in peripheral blood from patients withgastric cancer using piRNAs as markers. Clin Biochem. 2011 Sep44(13):1050-7.doi: 10.1016/j.clinbiochem.2011.06.004. Epub 2011 Jun 17. PubMed PMID: 21704610.

序号项目名称计划起始日期计划完成日期项目编号项目来源1新型标志物lncRNA在胃癌辅助诊断中的临床价值分析2014-06-012016-06-302014C33222省科技厅/公益技术应用研究2长链非编码RNA影响胃癌细胞生长的机制研究2013-01-012014-12-31CBSKL201306国家重点实验室/开放基金3长链非编码RNA影响胃癌发生的机制研究2012-02-012013-12-312012A610207市科技局/自然科学基金4胃癌相关长链非编码RNA的鉴定2011-12-012013-11-01XKL11D2127学科项目/市级重点5实时定量检测外周血中肿瘤相关非编码RNA的方法研究2008-01-012009-12-012008F70052省科技厅/其他6胃癌相关微小RNA的功能分析2008-01-012010-12-01Y207244省自然科学基金/一般项目