科研工作:
主要从事胰岛beta细胞功能与存活、脑-胃肠-胰腺轴与胰岛素抵抗、胰岛移植后存活的研究。主要发现:雌激素通过非经典的、非雌激素反应元件介导的、快速核外非基因组通路保护胰岛细胞的存活和功能,证实雌激素通过减少移植后胰岛的凋亡和促进胰岛血管再生而促进移植胰岛的植入及植入后的功能和存活。系列论文发表于Diabetes、Diabetologia、Endocrinology、Journal of clinical investigation, 及PNAS等。
1.Suhuan Liu, Gamze Kilic, Matthew Meyers, et al. Estrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia, 2012 Nov 12.
2.Joseph P. Tiano, Viviane Delghingaro-Augusto, Cedric Le May, Suhuan Liu, et al. Estrogen receptors activation reduces pancreatic islet lipogenesis and prevents β-cell failure in a model of type-2 diabetes. Journal of Clinical Investigation. 2011 Aug 1.
3.Winifred P.S. Wong, Joseph P. Tiano, Suhuan Liu, et al. The extranuclear estrogen receptor-α stimulates NeuroD1binding to the insulin promoter and favors insulin synthesis. Proceedings of the National Academy of Sciences of the United States of America. 2010,June 29.
4.Suhuan Liu, Guadalupe Navarro, Franck Mauvais-Jarvis. Androgen excess produces systemic oxidative stress and predisposes β -cell failure in female mice. PLoS ONE. 2010 Jun 24.
5.Hanaa Sallam, Hermes Oliveira, Suhuan Liu, et al. Mechanisms of Burn-induced Impairment in Gastric Slow Waves and Emptying in Rats. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2010 Apr 28.
6.Suhuan Liu, Cedric Le May, Winifred P.S. Wong, et al. Importance of extranuclear estrogen receptor-α and membrane G protein-coupled estrogen receptor in pancreatic islet survival。Diabetes. 2009 Jul 8.
7.Suhuan Liu, Franck Mauvais-Jarvis. Rapid, nongenomic estrogen actions protect pancreatic islet survival. Islets. (3) Nov, 2009。
8.Suhuan Liu, Franck Mauvais-Jarvis. Estrogenic Protection of {beta}-Cell Failure in Metabolic Diseases. Endocrinology.
9.Jing Zhang*, Suhuan Liu*, et al. Optimal Locations and Parameters of Gastric Electrical Stimulation in Altering Ghrelin and Oxytocin in the Hypothalamus in Rats. * Equal contribution authors. Neuroscience Research. 2008 Dec62(4):262-9. Epub 2008 Sep 26.
10.Suhuan Liu, Ming Tang, Shangmin Tao, et al. Central expression of ghrelin and cholecystokinin in rats with gastric electrical stimulation. Obes Surg. 2008 Jan18(1):109-14. Epub 2007 Dec 15.
教育背景:
2002年获吉林大学病理学与病理生理学专业医学博士学位。2005年9月至2011年8月,先后任职于美国德克萨斯大学医学院消化内科及西北大学内分泌系博士后,西北大学内分泌系研究助理教授及西北大学肥胖中心啮齿动物代谢表型研究中心副主任。现就职于厦门大学附属第一医院糖尿病研究所。