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GigaScience aims to revolutionize data dissemination, organization, understanding, and use. An online open-access open-data journal, we publish 'big-data' studies from the entire spectrum of life and biomedical sciences. To achieve our goals, the journal has a novel publication format: one that links standard manuscript publication with an extensive database ([GigaDB](http://gigadb.org/)) that hosts all associated data, as well as provides data analysis tools through our [GigaGalaxy](http://galaxy.cbiit.cuhk.edu.hk/) server. Further promoting transparency in the review process, we have open review as standard for all our peer-reviewed papers. Our scope covers not just 'omic' type data and the fields of high-throughput biology currently serviced by large public repositories, but also the growing range of more difficult-to-access data, such as imaging, neuroscience, ecology, cohort data, systems biology and other new types of large-scale shareable data.