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The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing materials that are related to cachexia and sarcopenia, as well as to body composition and its physiological and pathophysiological changes during the lifespan and in response to different illnesses from all fields of the life sciences. The term cachexia describes involuntary weight loss that is observed in the course of many chronic diseases, and is one of the most debilitating and life-threatening aspects of various illnesses at advanced stages. Cachexia, wasting syndromes and sarcopenia are becoming a concerning challenge for an increasing number of patients, their relatives and the medical teams caring for them. The Journal of Cachexia, Sarcopenia and Muscle aims to offer a reliable resource to all professionals who are interested in related research or who are involved in the clinical care of affected patients, for example those suffering from AIDS, cancer, chronic heart failure, chronic lung disease, liver cirrhosis, chronic kidney failure, rheumatoid arthritis, or sepsis. Alterations in body composition, particularly those affecting skeletal muscle, are key elements in the ageing process and in the pathophysiology of several chronic illnesses. Sarcopenia, i.e. loss of functional muscle mass without weight loss, is part of the ageing process and may play a role in reduced physical performance, falls, and disability. Studies on the functional importance of fat tissue and mechanisms leading to lipolysis are equally of interest as are studies on mechanisms of muscle wasting. The pathophysiology of cachexia involves a complex interaction between disease and body. Consequently, numerous potential therapeutic approaches are being considered and developed. Diagnostic and assessment approaches also involve researchers and clinicians seeking better screening and evaluation options and enhanced biomarkers through validated complementary investigations. This makes the Journal of Cachexia, Sarcopenia and Muscle a reliable resource of information for physicians, biochemists, biologists, dieticians, pharmacologists, and students dealing with cachexia, wasting and sarcopenia in various diseases.