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The Journal of Pathology aims to serve as a translational bridge between basic biomedical science and clinical medicine with particular emphasis on, but not restricted to, tissue based studies. The main interests of the Journal lie in publishing studies that further our understanding the pathophysiological and pathogenetic mechanisms of human disease. The Journal welcomes investigative studies on human tissues, in vitro and in vivo experimental studies, and investigations based on animal models with a clear relevance to human disease, including transgenic systems. In general, hypothesis driven studies that appropriately employ multiple investigative techniques are preferred over those that rely on a single methodology. As well as original research papers, the Journal seeks to provide rapid publication in a variety of other formats, including editorials, review articles, commentaries and perspectives and other features, both contributed and solicited. Purely descriptive papers on diagnostic pathology (including case reports and prognostic papers without mechanistic and experimental insights) are not considered central to the Journal’s purpose. Correspondence relating to papers published in the Journal will be considered, but only if of general interest. Such correspondance may be published in online versions only, at the Editor's discretion. In determining content, the primary considerations are excellence, relevance and novelty. As the journal of The Pathological Society, it seeks to reflect the broad scientific interests of the Society’s membership but its ethos, authorship, content and purpose are those expected of a leading publication in the international scientific literature.