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CMGH is the newest peer-reviewed journal published by the American Gastroenterological Association (AGA), joining Gastroenterology and Clinical Gastroenterology and Hepatology. The mission of CMGH is to publish impactful digestive biology research that ranges from mechanisms of normal function to pathobiology and covers a broad spectrum of themes in gastroenterology, hepatology, and pancreatology. The journal reports the latest advances in cell biology, immunology, physiology, microbiology, genetics, and neurobiology of gastrointestinal, hepatobiliary, and pancreatic health and disease. The research CMGH publishes is hypothesis driven, mechanistically novel, and appropriately designed and powered. Studies published in CMGH address important questions using tissues or cells from patients or animal models in order to make fundamental discoveries and translate them to human disease.